Anti-PEP1 antibody [18C8BC7AD10]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PEP1 also known as peptide 1 is an enzyme with a molecular mass of approximately 50 kDa. It catalyzes the hydrolysis of peptide bonds which is essential for protein metabolism. PEP1 shows expression in several tissues with high levels detected in the liver and kidneys. The enzyme is responsible for breaking down specific peptide substrates contributing to the regulation of peptide levels within cells.

Biological function summary

PEP1 helps regulate neuropeptide activity and peptide hormone degradation processes. It does not appear to be part of a larger protein complex but its activity still balances peptide turnover in the body. Its enzyme action ensures that peptides do not accumulate to potentially harmful levels therefore keeping cellular environments stable.

Pathways

PEP1 participates in key metabolic and signaling pathways such as the neuropeptide signaling pathway and the renin-angiotensin system. In these pathways PEP1 interacts with related proteins such as angiotensin-converting enzyme (ACE) to help control blood pressure and maintain homeostasis. Its functional role in these pathways situates PEP1 as a mediator of diverse physiological processes.

Associated diseases and disorders

PEP1 has connections to conditions such as hypertension and metabolic syndrome. Dysfunction or altered activity of PEP1 can affect peptide metabolism influencing blood pressure regulation and metabolic balance. The enzyme's association with ACE implies that alterations in PEP1 activity may contribute to or exacerbate these conditions. Understanding its function could provide insights into therapeutic strategies for managing these diseases.