Anti-Pepsinogen I antibody [7G3]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Pepsinogen I often referred to simply as pepsinogen is a zymogen form of the digestive enzyme pepsin. It possesses a molecular mass of approximately 44 kDa. This inactive precursor is synthesized and secreted by the gastric chief cells located in the stomach lining. Once released into the gastric lumen pepsinogen undergoes conversion into the active enzyme pepsin when exposed to the acidic pH of the stomach which facilitates protein breakdown during digestion.

Biological function summary

Pepsinogen I serves as an important component in the proteolytic process within the digestive system. It is not a part of a larger protein complex but functions independently after its activation. The conversion to pepsin enables the digestion of dietary proteins into smaller peptides and amino acids which are essential for the absorption and utilization by the body. This activity is fundamental to maintaining efficient nutrient processing and absorption in the gastrointestinal tract.

Pathways

The digestive process involving pepsinogen I is closely tied to the gastric acid secretion pathway. The enzyme pepsin derived from pepsinogen plays an important role in this pathway by breaking down proteins within the acidic environment of the stomach. Additionally pepsinogen activation indirectly interacts with other enzymes like gastric lipase which aids in the digestion of fats highlighting the interconnectedness of digestive pathways that ensure the body efficiently utilizes nutrients.

Associated diseases and disorders

Pepsinogen I levels may be associated with conditions like gastritis and peptic ulcer disease. Aberrant expression or secretion can serve as a marker for these gastric disorders where pepsinogen I through its converted form pepsin can be involved in the excessive breakdown of the stomach lining. Additionally its relationship with gastric-related proteins like mucins which protect against acidic damage further accentuates its significance in maintaining gastric health and the potential implications when balance is disrupted.