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AB135862

Anti-Pepsinogen II/PGC antibody

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(2 Publications)

Rabbit Polyclonal Pepsinogen II/PGC antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PGC.

View Alternative Names

Gastricsin, Pepsinogen C, PGC

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen II/PGC antibody (AB135862)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen II/PGC antibody (AB135862)

Immunohistochemical analysis of Paraffin-embedded Human lung carcinoma tissue labelling Pepsinogen II/PGC with ab135862 at 1/50 dilution.

Western blot - Anti-Pepsinogen II/PGC antibody (AB135862)
  • WB

Unknown

Western blot - Anti-Pepsinogen II/PGC antibody (AB135862)

All lanes:

Western blot - Anti-Pepsinogen II/PGC antibody (ab135862) at 1/500 dilution

All lanes:

Jurkat cell extract at 30 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human PGC. The exact immunogen used to generate this antibody is proprietary information.

P20142

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Alternative Products

Primary Antibodies

AB255826

Anti-Pepsinogen II/PGC antibody [EPR22843-269]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen II/PGC antibody [EPR22843-269] (AB255826)

  • 0
  • 0
Primary Antibodies

AB259997

Anti-Pepsinogen II/PGC antibody [EPR22843-269] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen II/PGC antibody [EPR22843-269] - BSA and Azide free (AB259997)

  • 0
  • 0

Complementary Products

Assay Kits

AB275552

Human PGC ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PGC ELISA Kit (AB275552)

  • 0
  • 0
Primary Antibodies

AB50123

Anti-Pepsinogen I antibody [7G3]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pepsinogen I antibody [7G3] (AB50123)

  • 4
  • 3
Proteins & Peptides

AB316513

Recombinant Human PGC Protein Standard (His tag)

Sandwich ELISA - Recombinant Human PGC Protein Standard (His tag) (AB316513)

  • 0
  • 0
Assay Kits

AB275552

Human PGC ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PGC ELISA Kit (AB275552)

  • 0
  • 0
Primary Antibodies

AB267474

Anti-TFF2 antibody [EPR23231-208]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TFF2 antibody [EPR23231-208] (AB267474)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab135862 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pepsinogen II also known as PGC or progastricsin functions as a digestive zymogen activated to pepsin in the acidic environment of the stomach. This enzyme precursor has a molecular mass of approximately 42-47 kDa. It is primarily expressed in the gastric chief cells and mucous cells of the stomach lining. Pepsinogen II plays an important role in the initial digestion of proteins breaking down complex protein molecules into peptides.
Biological function summary

Pepsinogen II contributes to digestive processes by converting into active pepsin at low pH levels facilitating protein degradation. Unlike some other digestive enzymes pepsin works independently from a complex. The production and secretion of pepsinogen II align with the gastric acid production ensuring efficient digestive activity. Its expression is vital for proper nutritional absorption and maintenance of gastrointestinal health.

Pathways

Pepsinogen II is closely involved in the proteolytic enzyme pathway. It connects with other gastric enzymes such as pepsin A through the activation processes influenced by gastric acid secretion. This interplay among digestive enzymes ensures optimal protein breakdown and nutrient absorption. The regulatory mechanisms that modulate gastric acid and pepsinogen secretion play an integral role in maintaining the digestive efficiency.

Pepsinogen II levels can serve as biomarkers for certain gastric conditions including gastritis and gastric cancer. Altered levels of pepsinogen II are associated with atrophic gastritis where reduced enzyme levels reflect damage to gastric mucosa. Also increased serum pepsinogen II concentration can indicate potential gastric cancer risk. These conditions highlight pepsinogen II's clinical importance in gastrointestinal disease diagnosis and management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hydrolyzes a variety of proteins.
See full target information PGC
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 22:796 PubMed34584571

2021

lncRNA CYTOR promotes cell proliferation and tumor growth via miR-125b/SEMA4C axis in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Tian,Xiaodong Yan,Long Yang,Zirong Liu,Zheyue Yuan,Yamin Zhang

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 24:666-679 PubMed33620602

2021

Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ombretta Repetto,Valli De Re,Paolo Giuffrida,Marco Vincenzo Lenti,Raffaella Magris,Marino Venerito,Agostino Steffan,Antonio Di Sabatino,Renato Cannizzaro
View all publications
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Product promise

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