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AB198270

Anti-PEPT2 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal PEPT2 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC15A2.

View Alternative Names

PEPT2, SLC15A2, Solute carrier family 15 member 2, Kidney H(+)/peptide cotransporter, Peptide transporter 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEPT2 antibody - C-terminal (AB198270)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEPT2 antibody - C-terminal (AB198270)

mmunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling PEPT2 with ab198270 at 1/30 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEPT2 antibody - C-terminal (AB198270)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEPT2 antibody - C-terminal (AB198270)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling PEPT2 with ab198270 at 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC15A2. The exact immunogen used to generate this antibody is proprietary information.

Q16348

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/15 - 1/50", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEPT2 also known as SLC15A2 is a peptide transporter protein critical for the reabsorption of di- and tripeptides. Mechanically it facilitates peptide transport across cell membranes using a proton gradient-driven mechanism. The protein has a molecular mass of approximately 86.5 kDa. PEPT2 is expressed mainly in the kidney and lung tissues where it plays an important role in nutrient absorption and drug pharmacokinetics.
Biological function summary

PEPT2 participates in the reabsorption and retention of small peptides and peptide-like drugs within cells. It acts as a transmembrane protein and is not known to be part of any larger complex. PEPT2 helps maintain peptide homeostasis by mediating the cellular uptake of short peptides derived from dietary proteins which ensures efficient nutrient recycling and impacts peptide metabolism.

Pathways

PEPT2 significantly contributes to cellular uptake in the nitrogen metabolism pathway and influences the pharmacological profiles of peptide-mimetic drugs in the body. It interacts with other peptide transporters like PEPT1 though PEPT2 operates with varying affinity and capacity particularly affecting the renal reabsorption pathways. Both PEPT2 and PEPT1 play a role in maintaining the body's peptide balance and regulating nitrogen compounds.

Researchers have found associations between PEPT2 function and certain disorders like cystinuria and oligopeptide transport defects. The abnormal activity or expression of PEPT2 can alter the absorption and excretion of key peptides leading to imbalance. In cystinuria for example PEPT2 might influence cystine reabsorption connected as well to cystine transport proteins suggesting altered handling of critical nitrogenous compounds in the disorder.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed : 16434549, PubMed : 18367661, PubMed : 7756356). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2 : 1 or 3 : 1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed : 7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed : 16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed : 31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane : catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed : 20406817).
See full target information SLC15A2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

EMBO reports 25:5383-5407 PubMed39424955

2024

Glycogenesis and glyconeogenesis from glutamine, lactate and glycerol support human macrophage functions.

Applications

Unspecified application

Species

Unspecified reactive species

Najia Jeroundi,Charlotte Roy,Laetitia Basset,Pascale Pignon,Laurence Preisser,Simon Blanchard,Cinzia Bocca,Cyril Abadie,Julie Lalande,Naïg Gueguen,Guillaume Mabilleau,Guy Lenaers,Aurélie Moreau,Marie-Christine Copin,Guillaume Tcherkez,Yves Delneste,Dominique Couez,Pascale Jeannin
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Product promise

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