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AB275580

PerCP Anti-CD2 antibody [127]

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(2 Publications)

Mouse Monoclonal CD2 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD2 aa 1-250.

View Alternative Names

CD2, SRBC, T-cell surface antigen CD2, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5

1 Images
Flow Cytometry - PerCP Anti-CD2 antibody [127] (AB275580)
  • Flow Cyt

Supplier Data

Flow Cytometry - PerCP Anti-CD2 antibody [127] (AB275580)

Flow cytometric analysis of human whole blood lymphocytes labeling CD2 with ab275580 at 5 μL per test (Black) compared to an isotype control (Grey). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

127

Isotype

IgG1

Conjugation

PerCP

Excitation/Emission

Ex: 490nm, Em: 675nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human CD2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P06729

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 5 μl/test.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.09% Sodium azide Constituents: 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD2 also known as T11 or LFA-2 acts as a cell surface glycoprotein expressed mainly on T-cells natural killer cells and thymocytes. This protein has a molecular mass of approximately 50-55 kDa. CD2 plays a critical role in facilitating cell-cell adhesion and signal transduction. It serves as a receptor for the CD58 ligand on antigen-presenting cells supporting the interaction between T-cells and these cells. By enhancing adhesion CD2 contributes to the formation of the immunological synapse necessary for effective immune response.
Biological function summary

The functioning of CD2 helps in the modulation of immune responses and T-cell activation. CD2 participates in signal transduction leading to cytokine production and proliferation. It is associated with the immunological synapse complex working closely with other surface molecules like Lck and CD3 to promote T-cell responses. This collaboration is vital for the development and function of immune cells driving adaptive immunity.

Pathways

CD2 engages in pathways integral to T-cell activation and signal transduction. A well-known pathway involving CD2 is the TCR (T-cell Receptor) signaling pathway where it partners with CD3 to initiate T-cell activation. Additionally CD2 influences the LAT (Linker for Activation of T-cells) pathway contributing to downstream signaling cascades that involve various signaling proteins such as Lck and ZAP-70 ensuring proper T-cell function.

CD2 shows connections to autoimmune diseases and cancers. For instance its involvement in abnormal T-cell activation links CD2 to autoimmune conditions like rheumatoid arthritis. Also various leukemias demonstrate altered CD2 expression suggesting a role in cancer pathogenesis. Through these disease states CD2's interaction with the CD58 protein becomes critical as this interaction affects the activity of T-cells in the disease milieu influencing disease progression and treatment outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
See full target information CD2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1619538 PubMed40895568

2025

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yifan Zhang,Jing Li,Xinglong Zhang,Xin Zhang,Jiali Li,Heng Li,Xin Zhao,Zihan Zhang,Yingyan Li,Keqi Chen,Shasha Peng,Haijing Shi,Longding Liu

Acta neuropathologica communications 12:35 PubMed38414005

2024

Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche.

Applications

Unspecified application

Species

Unspecified reactive species

Kelin Gonçalves de Oliveira,Anna Bång-Rudenstam,Sarah Beyer,Axel Boukredine,Hugo Talbot,Valeria Governa,Maria C Johansson,Ann-Sofie Månsson,Karin Forsberg-Nilsson,Johan Bengzon,Johan Malmström,Charlotte Welinder,Mattias Belting
View all publications
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