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AB65951

PerCP Anti-CD4 antibody [MEM-241]

3

(4 Reviews)

|

(3 Publications)

Mouse Monoclonal CD4 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Cynomolgus monkey, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD4.

View Alternative Names

CD4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-241

Isotype

IgG1

Light chain type

kappa

Conjugation

PerCP

Excitation/Emission

Ex: 490nm, Em: 675nm

Carrier free

No

Reacts with

Human, Cynomolgus monkey

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human CD4. The exact immunogen used to generate this antibody is proprietary information.

P01730

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/percp-mouse-igg1-kappa-monoclonal-b11-6-isotype-control-ab118658'>ab118658</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" }, "Cynomolgus monkey": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/percp-mouse-igg1-kappa-monoclonal-b11-6-isotype-control-ab118658'>ab118658</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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Product details

The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions.
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
purity >95% by SDS-PAGE.
Storage buffer
Preservative: 0.097% Sodium azide Constituents: PBS, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed : 12089508, PubMed : 16331979, PubMed : 2214026, PubMed : 9641677). Down-regulated by HIV-1 Vpu (PubMed : 17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed : 7909607).
See full target information CD4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cells 9: PubMed31905895

2019

Octyl Gallate Induces Pancreatic Ductal Adenocarcinoma Cell Apoptosis and Suppresses Endothelial-Mesenchymal Transition-Promoted M2-Macrophages, HSP90α Secretion, and Tumor Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Kee Voon Chua,Chi-Shuan Fan,Chia-Chi Chen,Li-Li Chen,Shu-Chen Hsieh,Tze-Sing Huang

The Journal of allergy and clinical immunology 133:1184-94 PubMed24388011

2014

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.

Applications

Flow Cyt

Species

Human

Luzheng Xue,Maryam Salimi,Isabel Panse,Jenny M Mjösberg,Andrew N J McKenzie,Hergen Spits,Paul Klenerman,Graham Ogg

Blood 116:4859-69 PubMed20798236

2010

Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.

Applications

Flow Cyt

Species

Human

Jean-Philippe Bastien,Gorazd Krosl,Cynthia Therien,Marissa Rashkovan,Christian Scotto,Sandra Cohen,David S Allan,Donna Hogge,R Maarten Egeler,Claude Perreault,Denis Claude Roy
View all publications
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