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Rabbit Recombinant Monoclonal CD48 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Cd48 aa 1 to C-terminus.

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Images

Flow Cytometry - PerCP Anti-CD48 antibody [341] (AB275666), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Conjugation
PerCP
Excitation/Emission
Ex: 490nm, Em: 675nm
Storage buffer

Preservative: 0.09% Sodium azide
Constituents: 0.5% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Fragment Protein within Mouse Cd48 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P18181

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Mouse
Tested

Tested
Tested

Species
Mouse
Dilution info
-
Notes

10 μl/Test.

Associated Products

Select an associated product type

1 product for Alternative Version

Target data

Function

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:21278219, PubMed:9881969). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:21278219, PubMed:9881969).

Alternative names

CD48, Bcm-1, Cd48, CD48 antigen, BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2, Signaling lymphocytic activation molecule 2, sgp-60, SLAMF2

Recommended products

Rabbit Recombinant Monoclonal CD48 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Cd48 aa 1 to C-terminus.

Key facts

Isotype
IgG
Conjugation
PerCP
Excitation/Emission
Ex: 490nm, Em: 675nm
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Fragment Protein within Mouse Cd48 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P18181
Clone number
341
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze, Store in the dark

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CD48 also known as SLAMF2 or B-lymphocyte activation marker BLAST-1 is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular mass approximately 45-70 kDa depending on glycosylation. It is expressed on the surface of various immune cells like T cells B cells and natural killer (NK) cells. CD48 does not possess an intracellular signaling domain but engages in extracellular interactions with other proteins affecting immune cell activities.

Biological function summary

CD48 serves as a co-stimulatory molecule involved in immune response modulation. It interacts with 2B4 (CD244) a member of the signaling lymphocyte activation molecule (SLAM) family to form a receptor-ligand complex. This interaction can result in enhanced T cell and NK cell responses. CD48's presence on activated hematopoietic and non-hematopoietic cells highlights its role in cell-to-cell communication.

Pathways

CD48 participates in SLAM family receptor signaling and natural killer cell-mediated cytotoxicity. In the SLAM pathway CD48 enhances communication and regulation between T cells and NK cells. This communication also relates to the roles of CD244 linking it to downstream signaling pathways that influence immune cell function. These pathways illustrate the critical network CD48 is part of which impacts various immune responses.

Associated diseases and disorders

CD48 is involved in autoimmune conditions like rheumatoid arthritis and immunological cancers such as lymphoma. In rheumatoid arthritis CD48 along with CD244 modulates immune responses which can exacerbate inflammation. In lymphoma abnormal CD48 expression can contribute to tumor progression and immune evasion indicating its potential as a therapeutic target.

Product promise

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1 product image

  • Flow Cytometry - PerCP Anti-CD48 antibody [341] (ab275666), expandable thumbnail

    Flow Cytometry - PerCP Anti-CD48 antibody [341] (ab275666)

    Flow cytometric analysis of CD48 expression on spleen lymphocytes. BALB/c splenocytes were treated with a mouse BD Fc Block purified anti-CD16/CD32 mAb 2.4G2 and stained with ab275666 at 10 μl/Test. The histogram were derived from the gated events based on light scattering characteristics of lymphocytes.

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Product protocols

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