Mouse Monoclonal CD24 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Human samples.
Images
![Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [SN3] (AB239339), expandable thumbnail](https://content.abcam.com/products/images/percp-cy55-cd24-antibody-sn3-ab239339--flow-cytometry-img78764.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [SN3] (AB239339)")
Key facts
- Isotype
IgG1
- Host species
Mouse
- Conjugation
PerCP
- Excitation/Emission
Ex: 490nm, Em: 675nm
- Storage buffer
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Human | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 4 µL for 106 Cells | Notes OR 100 μl of whole blood. |
Associated Products
Select an associated product type
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5 products for Alternative Product
Target data
Function
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
Alternative names
Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24A
Recommended products
Mouse Monoclonal CD24 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Human samples.
Alternative names
Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24A
Key facts
- Isotype
IgG1
- Host species
Mouse
- Conjugation
PerCP
- Excitation/Emission
Ex: 490nm, Em: 675nm
- Storage buffer
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
- Clone number
SN3
- Purification technique
Size-exclusion chromatography
- Concentration
- Purification notes
The purified antibody is conjugated with tandem dye PerCP-Cy™5.5 under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store in the dark
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- Activity summary
CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.
- Biological function summary
CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.
- Pathways
CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.
- Associated diseases and disorders
CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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1 product image
![Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339), expandable thumbnail](https://content.abcam.com/products/images/percp-cy55-cd24-antibody-sn3-ab239339--flow-cytometry-img78764.jpg "Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339)")
Flow Cytometry - PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339)
Flow Cytometric analysis of human peripheral blood cells labeling CD24 with ab239339. Surface staining.
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