JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB210337

PerCP/Cy5.5® Anti-NKR-P1C antibody [PK136]

Be the first to review this product! Submit a review

|

(3 Publications)

Mouse Monoclonal NKR-P1C antibody - conjugated to PerCP/Cy5.5®. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 3 publications.

View Alternative Names

CD161c, Ly55c, Nkrp1c, Klrb1c, Killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, Lymphocyte antigen 55c, NK1.1, NKR-P1.9, NKR-P1C, Natural killer cell surface protein P1-40, Ly-55c, NKR-P1 40

1 Images
Flow Cytometry - PerCP/Cy5.5® Anti-NKR-P1C antibody [PK136] (AB210337)
  • Flow Cyt

Supplier Data

Flow Cytometry - PerCP/Cy5.5® Anti-NKR-P1C antibody [PK136] (AB210337)

Flow Cytometric analysis of Mouse C57Bl/6 spleen cells labeling NKR-P1C with FITC anti-Mouse CD3e antibody and ab210337 at 0.25 μg (right panel) or PerCP/Cy5.5® Mouse IgG2a isotype control at 0.25 μg (left panel).

  • Carrier free

    Anti-NKR-P1C antibody [PK136] - BSA and Azide free

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PK136

Isotype

IgG2a

Light chain type

kappa

Conjugation

PerCP/Cy5.5®

Excitation/Emission

Ex: 482nm, Em: 695nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

style
left-column

Alternative Products

Primary Antibodies

AB25026

FITC Anti-NKR-P1C antibody [PK136]

  • 1
  • 1

Complementary Products

Primary Antibodies

AB233046

Alexa Fluor® 647 Anti-CD11c antibody [N418]

Flow Cytometry - Alexa Fluor® 647 Anti-CD11c antibody [N418] (AB233046)

  • 0
  • 0
Primary Antibodies

AB234107

Anti-CD161 antibody [EPR21236]

BOND RX™ Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody [EPR21236] (AB234107)

  • 4
  • 2
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB197979

Anti-CD161 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD161 antibody (AB197979)

  • 4
  • 3
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Suggested use 0.25 μg.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab210337 was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NKR-P1C also known as NK1.1 is a C-type lectin-like receptor expressed on the surface of natural killer (NK) cells and some T cells. In mice this protein has a molecular mass of approximately 30 to 46 kDa. Researchers often focus on its distribution in cellular compartments which includes lymphoid tissues such as the spleen and thymus. This receptor is known for playing a role in the regulation of immune responses by enabling NK cells to recognize and eliminate target cells.
Biological function summary

NKR-P1C is critical in the activation and inhibition of natural killer cell functions. This protein does not operate alone but often functions as part of an immune receptor complex. It contributes to the balance between activating and inhibitory signals that determine NK cell responses. NKR-P1C can bind to ligands that influence the cytotoxic activity of these cells toward infected or malignant cells.

Pathways

NKR-P1C integrates into important immune signaling pathways such as the NK cell-mediated cytotoxicity pathway. This pathway involves interactions with other receptors like Ly49 and NKG2D which modulate NK cell activities. NKR-P1C plays an essential role in transmitting signals that lead to the release of cytokines and the destruction of afflicted cells coordinating with these receptors to execute immune functions.

NKR-P1C has associations with cancer and viral infections where it influences NK cell interventions against pathologies. During tumor development or viral infection NKR-P1C may change expression patterns potentially affecting immune surveillance and responses. It works in tandem with proteins like perforin and granzymes which are involved in inducing cell death in target cells making it a significant player in immune responses to malignancies and persistent viruses.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
See full target information Klrb1c
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 16:1611637 PubMed40693271

2025

Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH.

Applications

Unspecified application

Species

Unspecified reactive species

Johnny Amer,Diana Abu Arra,Ahmad Salhab,Faris Kayed,Muneer Maali,Raghad Shweiki,Mustafa Ghanim

The Tohoku journal of experimental medicine : PubMed40571642

2025

Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Zhou,Shanshan Xu,Juan Tang,Xiaomei Han,Yu Jiang,Huaying Chen

The Journal of clinical investigation 130:3021-3037 PubMed32364537

2020

Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Takehiko Shibata,Airi Makino,Ruiko Ogata,Shigeki Nakamura,Toshihiro Ito,Kisaburo Nagata,Yoshihiko Terauchi,Taku Oishi,Mikiya Fujieda,Yoshimasa Takahashi,Manabu Ato
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com