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AB219299

Anti-Perilipin 2 antibody [ADFP/1366]

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(1 Publication)

Mouse Monoclonal Perilipin-2 antibody. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLIN2 aa 200-400.

View Alternative Names

ADFP, PLIN2, Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Perilipin 2 antibody [ADFP/1366] (AB219299)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Perilipin 2 antibody [ADFP/1366] (AB219299)

Immunohistochemical analysis of paraffin embedded, formalin fixed Human adrenal tissue labeling Perilipin-2 using ab219299 at 1 μg/ml

Protein Array - Anti-Perilipin 2 antibody [ADFP/1366] (AB219299)
  • Protein Array

Unknown

Protein Array - Anti-Perilipin 2 antibody [ADFP/1366] (AB219299)

ab219299 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14 then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ADFP/1366

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Protein Array, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PLIN2 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q99541

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Alternative Products

Primary Antibodies

AB201721

HRP Anti-Perilipin 2 antibody [EPR3713]

RabMAb|Recombinant

Western blot - HRP Anti-Perilipin 2 antibody [EPR3713] (AB201721)

  • 0
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Primary Antibodies

AB108323

Anti-Perilipin 2 antibody [EPR3713]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

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  • 3
Primary Antibodies

AB232483

Anti-Perilipin 2 antibody [EPR3713] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Perilipin 2 antibody [EPR3713] - BSA and Azide free (AB232483)

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  • 0

Complementary Products

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Secondary Antibodies

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Primary Antibodies

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Anti-alpha smooth muscle Actin antibody [1A4]

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Primary Antibodies

AB8227

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Primary Antibodies

AB3526

Anti-Perilipin-1 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>", "ProteinArray-species-checked": "guaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Recombinant full length protein - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Perilipin-2 also known as PLIN2 ADFP or adipophilin has an approximate molecular weight of 48 kDa. It is primarily expressed in tissues involved in lipid metabolism like adipose tissue liver and muscle. The main role of Perilipin-2 is to coat lipid droplets in cells thereby regulating lipid storage and breakdown. This protein serves as a critical component of the lipid droplet surface providing structure and protecting the lipid core from excessive unregulated lipolysis.
Biological function summary

Perilipin-2 is a member of the PAT family proteins involved in lipid droplet formation and maintenance. It does not typically form part of larger complexes but it plays a significant role in cellular energy regulation by controlling lipid reserves. This regulation ensures an efficient balance between energy storage and mobilization. The presence and levels of Perilipin-2 can influence how cells respond to nutrients particularly during periods of energy surplus or fasting.

Pathways

Perilipin-2 is heavily involved in the regulation of lipid metabolic pathways and the storage-related signaling cascades. It interacts with key metabolic proteins including hormone-sensitive lipase (HSL) to modulate lipolysis. By doing so Perilipin-2 influences processes like fatty acid mobilization and glycerol release integrating perfectly into the cellular energy balance system. The protein is also related to perilipin another member of the lipid droplet-associated proteins emphasizing its participation in lipid metabolism.

Altered expression of Perilipin-2 can have implications in obesity and fatty liver disease. The protein is involved in the accumulation of lipid droplets which is a common feature in these conditions. Obesity and associated disorders often show elevated levels of Perilipin-2 which mirrors increased lipid storage capacity. The protein’s interplay with adipose tissue composition highlights its connection to obesity-related factors including other lipid droplet-associated proteins like adipose triglyceride lipase (ATGL) which influence the progression of metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
See full target information PLIN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:238 PubMed36646707

2023

Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation.

Applications

Unspecified application

Species

Unspecified reactive species

Xinwei Liu,Yingying Ye,Liling Zhu,Xiaoyun Xiao,Boxuan Zhou,Yuanting Gu,Hang Si,Huixin Liang,Mingzhu Liu,Jiaqian Li,Qiongchao Jiang,Jiang Li,Shubin Yu,Ruiying Ma,Shicheng Su,Jian-You Liao,Qiyi Zhao
View all publications
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Product promise

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