AB108323

Anti-Perilipin 2 antibody [EPR3713]

Name: Anti-Perilipin 2 antibody [EPR3713] (ab108323) | Abcam
Brand: Abcam Limited
SKU: AB108323
Price: 415 USD
Availability: InStock
Rating: 4 (3 reviews)

RabMAb
Recombinant
20ul selling size
What is this?

(3 Reviews)

(64 Publications)

Anti-Perilipin 2 antibody [EPR3713] (ab108323) is a rabbit monoclonal antibody detecting Perilipin-2 in Western Blot. Suitable for Human, Mouse, Rat.

- Biophysical QC for unrivalled batch-batch consistency
- Over 40 publications

View Alternative Names

ADFP, PLIN2, Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP

2 Images

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Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

Lanes 1 - 4:

Western blot - Anti-Perilipin 2 antibody [EPR3713] (ab108323) at 1/1000 dilution

Lanes 1 - 4:

Western blot - Anti-Perilipin 2 antibody [EPR3713] - BSA and Azide free (<a href='/en-us/products/primary-antibodies/perilipin-2-antibody-epr3713-bsa-and-azide-free-ab232483'>ab232483</a>) at 1/1000 dilution

Lane 1:

Human fetal liver lysate at 10 µg

Lane 2:

HepG2 lysate at 10 µg

Lane 3:

JAR lysate at 10 µg

Lane 4:

Human milk lysate at 10 µg

Predicted band size: 48 kDa

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Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

All lanes:

Western blot - Anti-Perilipin 2 antibody [EPR3713] (ab108323) at 1/1000 dilution

Lane 1:

Mouse brain lysate at 10 µg

Lane 2:

Rat brain lysate at 10 µg

Predicted band size: 48 kDa

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HRP

HRP Anti-Perilipin 2 antibody [EPR3713]
Carrier free

Anti-Perilipin 2 antibody [EPR3713] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3713

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

What is this antibody validated in?
Anti-Perilipin 2 antibody [EPR3713] (ab108323) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse, Rat samples.

What is the molecular weight of Perilipin-2?
Anti-Perilipin 2 [EPR3713] (ab108323) specifically detects a band for Perilipin-2 (UniProt: Q99541) at a molecular weight of 48kDa.

Trusted by the scientific community
Anti-Perilipin 2 [EPR3713] (ab108323) was first used in a scientific publication in 2011 and has been cited over 40 times in peer-reviewed journals.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Other related products
We have a range of other formats of antibody clone [EPR3713] also available for your convenience: ab108323, HRP - ab201721, Carrier free - ab232483

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Perilipin-2 also known as PLIN2 ADFP or adipophilin has an approximate molecular weight of 48 kDa. It is primarily expressed in tissues involved in lipid metabolism like adipose tissue liver and muscle. The main role of Perilipin-2 is to coat lipid droplets in cells thereby regulating lipid storage and breakdown. This protein serves as a critical component of the lipid droplet surface providing structure and protecting the lipid core from excessive unregulated lipolysis.

Biological function summary

Perilipin-2 is a member of the PAT family proteins involved in lipid droplet formation and maintenance. It does not typically form part of larger complexes but it plays a significant role in cellular energy regulation by controlling lipid reserves. This regulation ensures an efficient balance between energy storage and mobilization. The presence and levels of Perilipin-2 can influence how cells respond to nutrients particularly during periods of energy surplus or fasting.

Pathways

Perilipin-2 is heavily involved in the regulation of lipid metabolic pathways and the storage-related signaling cascades. It interacts with key metabolic proteins including hormone-sensitive lipase (HSL) to modulate lipolysis. By doing so Perilipin-2 influences processes like fatty acid mobilization and glycerol release integrating perfectly into the cellular energy balance system. The protein is also related to perilipin another member of the lipid droplet-associated proteins emphasizing its participation in lipid metabolism.

Altered expression of Perilipin-2 can have implications in obesity and fatty liver disease. The protein is involved in the accumulation of lipid droplets which is a common feature in these conditions. Obesity and associated disorders often show elevated levels of Perilipin-2 which mirrors increased lipid storage capacity. The protein's interplay with adipose tissue composition highlights its connection to obesity-related factors including other lipid droplet-associated proteins like adipose triglyceride lipase (ATGL) which influence the progression of metabolic diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

See full target information PLIN2

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Publications (64)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113405 PubMed40978144

2025

Histone demethylase LSD1 regulates lipid homeostasis during infection.

Applications

Unspecified application

Species

Unspecified reactive species

Gaurav Kumar Lohia,Awantika Shah,Kithiganahalli Narayanaswamy Balaji

Journal of biomedical science 32:89 PubMed40936093

2025

Ether-lipids accumulation promotes hepatocellular carcinoma progression linked to PPARα deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Pei-Yin Liao,Wen-Jen Lin,Pei-Chun Shen,Cian-Ru Yang,Ying-Chun Yu,Chun-Chieh Yeh,Long-Bin Jeng,Hsieh-Chou Lai,Wei-Chung Cheng,Wen-Lung Ma

Antioxidants (Basel, Switzerland) 14: PubMed40298797

2025

Replicative Senescence in Mesenchymal Stem Cells: An In Vitro Study on Mitochondrial Dynamics and Metabolic Alterations.

Applications

Unspecified application

Species

Unspecified reactive species

Beatrice Casorati,Isabella Zafferri,Sara Castiglioni,Jeanette A Maier

Nature communications 16:3089 PubMed40164598

2025

Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaotao Zhang,Huaming Li,Yichen Gu,An Ping,Jiarui Chen,Qia Zhang,Zhouhan Xu,Junjie Wang,Shenjie Tang,Rui Wang,Jianan Lu,Lingxiao Lu,Chenghao Jin,Ziyang Jin,Jianmin Zhang,Ligen Shi

Diabetes, metabolic syndrome and obesity : targets and therapy 18:583-599 PubMed40026899

2025

Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Dong Zhao,Zhao-Hui Fang

Cell death & disease 16:14 PubMed39809738

2025

The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xudong Sha,Jiayuan Lin,Kexin Wu,Jia Lu,Zhihua Yu

The Journal of cell biology 224: PubMed39535446

2024

Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Florent Arbogast,Raquel Sal-Carro,Wacym Boufenghour,Quentin Frenger,Delphine Bouis,Louise Filippi De La Palavesa,Jean-Daniel Fauny,Olivier Griso,Hélène Puccio,Rebecca Fima,Thierry Huby,Emmanuel L Gautier,Anne Molitor,Raphaël Carapito,Seiamak Bahram,Nikolaus Romani,Björn E Clausen,Benjamin Voisin,Christopher G Mueller,Frédéric Gros,Vincent Flacher

International journal of molecular sciences 25: PubMed39337328

2024

3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Stéphanie Gaigé,Anne Abysique,Rym Barbouche,Alain Tonetto,Attilio Di Maio,Maxime Robin,Anh-Tuan Lormier,Jean-Denis Troadec

International journal of biological sciences 20:4654-4673 PubMed39309435

2024

MicroRNA-29b Plays a Vital Role in Podocyte Injury and Glomerular Diseases through Inducing Mitochondrial Dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Jiafeng Liu,Yabing Xiong,Hongyan Mo,Hongxin Niu,Jinhua Miao,Weiwei Shen,Shan Zhou,Xiaoxu Wang,Xiaolong Li,Yunfang Zhang,Kunling Ma,Lili Zhou

The Journal of biological chemistry 300:107731 PubMed39216628

2024

Delineation of the substrate recognition domain of MARCHF6 E3 ubiquitin ligase in the Ac/N-degron pathway and its regulatory role in ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jihye Yang,Sang-Yoon Kim,Cheol-Sang Hwang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Perilipin 2 antibody [EPR3713]

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

Related conjugates and formulations (2)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (64)

Product promise