AB39374

Anti-Peripherin antibody

5

(7 Reviews)

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(30 Publications)

Chicken Polyclonal Peripherin antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 30 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Prph.

View Alternative Names

Prph1, Prph, Peripherin

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-Peripherin antibody (AB39374)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Peripherin antibody (AB39374)

ab39374 staining human peripherin in neonatal rat cortical neurons cultured for 14-21 days by ICC/IF.

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Reacts with

Rat

Applications

ICC/IF

Immunogen

Recombinant Full Length Protein corresponding to Rat Prph.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Peripherin also known as 8G2 or 7C5 is a protein expressed strongly in peripheral and certain central nervous system neurons. The mass of the peripherin protein is approximately 57 kDa. This intermediate filament protein structurally supports neurons aiding in their proper formation maintenance and regeneration. Peripherin localizes to the axons of mature neurons and serves important functions in the neuronal cytoskeleton and its stability.

Biological function summary

Peripherin impacts the nervous system's structure and dynamics. As part of the cytoskeleton it contributes to neurofilament networks which are essential for neuronal shape and mechanical integrity. Peripherin plays a role in neuronal differentiation and apoptosis. It operates independently but occasionally interacts with other cytoskeletal proteins like neurofilament light protein to perform its duties in neuronal cells.

Pathways

Peripherin is involved in processes associated with neuronal development and injury response. It features in neurogenesis pathways where it influences the growth and repair of axons. Peripherin interacts with proteins such as vimentin which helps manage cell dynamics and stress responses. The axonal transport pathway also utilizes peripherin to support axonal transport under stressful conditions ensuring cellular integrity and function.

Peripherin connects strongly to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Its overexpression or aggregation can create abnormal filamentous structures that contribute to motor neuron degeneration. In ALS peripherin may interact with TAR DNA-binding protein 43 (TDP-43) and superoxide dismutase 1 (SOD1) proteins known to be significant in the disease pathogenesis. Understanding peripherin’s role in these diseases aids in unraveling mechanisms underlying neuronal degeneration.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Class-III neuronal intermediate filament protein (PubMed : 2624740, PubMed : 3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed : 2585054, PubMed : 7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).

See full target information Prph

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Publications (30)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 45: PubMed40816765

2025

Peripheral Gating of Nociception Investigated with a Decerebrate, Arterially Perfused Preparation of the Rat.

Applications

Unspecified application

Species

Unspecified reactive species

Varinder K Lall,Pierce Mullen,Stephen W Milne,Hao Han,Xiaona Du,Nikita Gamper

Nature communications 16:5433 PubMed40595635

2025

SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Li Liu,Zhigang Gao,Xueyuan Niu,Hong Yu,Xiaolong Xin,Yanlan Gu,Genghai Ma,Yan Gu,Yijun Liu,Sanhua Fang,Till Marquardt,Liang Wang

Scientific reports 14:25166 PubMed39448766

2024

A primate model animal revealed the inter-species differences and similarities in the subtype specifications of the spiral ganglion neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Makoto Hosoya,Masafumi Ueno,Marie N Shimanuki,Takanori Nishiyama,Naoki Oishi,Hiroyuki Ozawa

Nature communications 15:8585 PubMed39362841

2024

The single-cell transcriptomic atlas iPain identifies senescence of nociceptors as a therapeutical target for chronic pain treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Prach Techameena,Xiaona Feng,Kaiwen Zhang,Saida Hadjab

Frontiers in pharmacology 15:1330167 PubMed38440182

2024

The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels.

Applications

Unspecified application

Species

Unspecified reactive species

Yating An,Jingyi Hu,Han Hao,Weixin Zhao,Xiaoxue Zhang,Jicheng Shao,Caixue Wang,Xinmeng Li,Chao Liu,Jinsha He,Yiwen Zhao,Hailin Zhang,Xiaona Du

PLoS biology 21:e3001958 PubMed36603052

2023

Dorsal root ganglia control nociceptive input to the central nervous system.

Applications

Unspecified application

Species

Unspecified reactive species

Han Hao,Rosmaliza Ramli,Caixue Wang,Chao Liu,Shihab Shah,Pierce Mullen,Varinder Lall,Frederick Jones,Jicheng Shao,Hailin Zhang,David B Jaffe,Nikita Gamper,Xiaona Du

The Journal of comparative neurology 530:3209-3225 PubMed36043843

2022

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy J Hibberd,Wai Ping Yew,Kelsi N Dodds,Zili Xie,Lee Travis,Simon J Brookes,Marcello Costa,Hongzhen Hu,Nick J Spencer

Neural development 17:6 PubMed35524278

2022

Early development of the cochlea of the common marmoset, a non-human primate model.

Applications

Unspecified application

Species

Unspecified reactive species

Makoto Hosoya,Masato Fujioka,Junko Okahara,Sho Yoshimatsu,Hideyuki Okano,Hiroyuki Ozawa

eLife 10: PubMed33470930

2021

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Schörnig,Xiangchun Ju,Luise Fast,Sebastian Ebert,Anne Weigert,Sabina Kanton,Theresa Schaffer,Nael Nadif Kasri,Barbara Treutlein,Benjamin Marco Peter,Wulf Hevers,Elena Taverna

Cell reports 32:107912 PubMed32697985

2020

Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction.

Applications

Unspecified application

Species

Unspecified reactive species

Niklas Michel,Pratibha Narayanan,Orr Shomroni,Manuela Schmidt

View all publications

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Product promise

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