Chicken Polyclonal Peripherin antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 21 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Prph.
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- PLoS biology 21:e30019582023Dorsal root ganglia control nociceptive input to the central nervous system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHan Hao,Rosmaliza Ramli,Caixue Wang,Chao Liu,Shihab Shah,Pierce Mullen,Varinder Lall,Frederick Jones,Jicheng Shao,Hailin Zhang,David B Jaffe,Nikita Gamper,Xiaona DuPubMed 36603052
- The Journal of comparative neurology 530:3209-32252022Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTimothy J Hibberd,Wai Ping Yew,Kelsi N Dodds,Zili Xie,Lee Travis,Simon J Brookes,Marcello Costa,Hongzhen Hu,Nick J SpencerPubMed 36043843
- Neural development 17:62022Early development of the cochlea of the common marmoset, a non-human primate model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMakoto Hosoya,Masato Fujioka,Junko Okahara,Sho Yoshimatsu,Hideyuki Okano,Hiroyuki OzawaPubMed 35524278
- eLife 10:2021Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Schörnig et. al.PubMed 33470930
- Cell reports 32:1079122020Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNiklas Michel,Pratibha Narayanan,Orr Shomroni,Manuela SchmidtPubMed 32697985
- Neurobiology of disease 142:1049612020ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRory Mitchell et. al.PubMed 32531343
- Scientific reports 10:65692020Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmiko Okuda-Ashitaka,Yuka Kakuchi,Hiroaki Kakumoto,Shota Yamanishi,Hiroki Kamada,Takafumi Yoshidu,Satoshi Matsukawa,Naoya Ogura,Sadahito Uto,Toshiaki Minami,Seiji Ito,Ken-Ichi MatsumotoPubMed 32300146
- Bio-protocol 9:e34542019Semi-automated Model to Accurately Counting Sympathetic Nervous Fibers.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDennis Bleck,Lkham Erdene-Byambadoo,Ralph Brinks,Matthias Schneider,Georg PongratzPubMed 33654949
- International journal of stem cells 12:410-4182019Regeneration of Neural Networks in Immature Teeth with Non-Vital Pulp Following a Novel Regenerative Procedure.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaha M F Mounir,Fatma M Rashed,Sahar M BukharyPubMed 31658509
- eLife 8:2019Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarolyn M Walsh et. al.PubMed 31631836
Key facts
- Isotype
- IgY
- Host species
- Chicken
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Rat Prph. Database link P21807
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Reactivity data
Select an application| ICC/IF | |
|---|---|
| Rat | Tested |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
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2 products for Alternative Product
Target data
Function
Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
Alternative names
Prph1, Prph, Peripherin
Recommended products
Chicken Polyclonal Peripherin antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 21 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Prph.
Key facts
- Isotype
- IgY
- Host species
- Chicken
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Rat Prph. Database link P21807
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Peripherin also known as 8G2 or 7C5 is a protein expressed strongly in peripheral and certain central nervous system neurons. The mass of the peripherin protein is approximately 57 kDa. This intermediate filament protein structurally supports neurons aiding in their proper formation maintenance and regeneration. Peripherin localizes to the axons of mature neurons and serves important functions in the neuronal cytoskeleton and its stability.
- Biological function summary
Peripherin impacts the nervous system's structure and dynamics. As part of the cytoskeleton it contributes to neurofilament networks which are essential for neuronal shape and mechanical integrity. Peripherin plays a role in neuronal differentiation and apoptosis. It operates independently but occasionally interacts with other cytoskeletal proteins like neurofilament light protein to perform its duties in neuronal cells.
- Pathways
Peripherin is involved in processes associated with neuronal development and injury response. It features in neurogenesis pathways where it influences the growth and repair of axons. Peripherin interacts with proteins such as vimentin which helps manage cell dynamics and stress responses. The axonal transport pathway also utilizes peripherin to support axonal transport under stressful conditions ensuring cellular integrity and function.
- Associated diseases and disorders
Peripherin connects strongly to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Its overexpression or aggregation can create abnormal filamentous structures that contribute to motor neuron degeneration. In ALS peripherin may interact with TAR DNA-binding protein 43 (TDP-43) and superoxide dismutase 1 (SOD1) proteins known to be significant in the disease pathogenesis. Understanding peripherin’s role in these diseases aids in unraveling mechanisms underlying neuronal degeneration.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry/ Immunofluorescence - Anti-Peripherin antibody (ab39374)
ab39374 staining human peripherin in neonatal rat cortical neurons cultured for 14-21 days by ICC/IF.
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