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AB238598

Anti-PEX1 antibody

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(1 Publication)

Rabbit Polyclonal PEX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX1 aa 900 to C-terminus.

View Alternative Names

Peroxisomal ATPase PEX1, Peroxin-1, Peroxisome biogenesis disorder protein 1, Peroxisome biogenesis factor 1, PEX1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-PEX1 antibody (AB238598)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PEX1 antibody (AB238598)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for PEX1 using ab238598 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX1 antibody (AB238598)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX1 antibody (AB238598)

Paraffin-embedded human placenta tissue stained for PEX1 with ab238598 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PEX1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43933

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PEX1 also known as Peroxisomal Biogenesis Factor 1 plays an important role in peroxisomal function. PEX1 has a molecular mass of around 145 kDa and is widely expressed in human tissues. It belongs to the family of ATPases associated with various cellular activities (AAAs) which are essential molecular machines involved in diverse biological processes. PEX1 localizes mainly to the peroxisomes which means it takes part in the mechanics of peroxisome assembly and function.
Biological function summary

PEX1 interacts in collaboration with other peroxisomal proteins to facilitate the import of matrix proteins into the peroxisome. It exists as part of a hetero-oligomeric complex with PEX6 another AAA protein which forms an important part of the peroxisome biogenesis mechanism. PEX1's function in this complex contributes to the assembly maintenance and selective import operations within the peroxisome which are critical for cellular homeostasis and lipid metabolism.

Pathways

PEX1 contributes significantly within the peroxisomal biogenesis pathway where it works alongside proteins like PEX2 and PEX6 to maintain the functionality of the peroxisomes. This pathway is pivotal in multiple biological functions including plasmalogen synthesis and the breakdown of very-long-chain fatty acids. These processes tie closely with broader cellular metabolic pathways impacting both energy regulation and lipid processing.

Defects in PEX1 are linked to peroxisome biogenesis disorders such as Zellweger syndrome spectrum. These disorders result from compromised peroxisomal function leading to severe clinical symptoms and often fatal outcomes. PEX1 mutations disrupt its interaction with PEX6 impairing peroxisome function. This highlights its important role in peroxisome-related diseases and provides potential targets for future therapeutic strategies to treat these metabolic conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed : 11439091, PubMed : 16314507, PubMed : 16854980, PubMed : 21362118, PubMed : 29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed : 29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed : 29884772).
See full target information PEX1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 7:eabf6063 PubMed34705506

2021

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Molly M Wilson,Céline Callens,Matthieu Le Gallo,Svetlana Mironov,Qiong Ding,Amandine Salamagnon,Tony E Chavarria,Roselyne Viel,Abena D Peasah,Arjun Bhutkar,Sophie Martin,Florence Godey,Patrick Tas,Hong Soon Kang,Philippe P Juin,Anton M Jetten,Jane E Visvader,Robert A Weinberg,Massimo Attanasio,Claude Prigent,Jacqueline A Lees,Vincent J Guen
View all publications
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