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AB211508

Anti-PEX11B antibody

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(3 Publications)

Rabbit Polyclonal PEX11B antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PEX11B aa 100-200.

View Alternative Names

Peroxisomal membrane protein 11B, Peroxin-11B, Peroxisomal biogenesis factor 11B, Protein PEX11 homolog beta, PEX11-beta, PEX11B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX11B antibody (AB211508)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX11B antibody (AB211508)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue labeling PEX11B with ab211508 at a 1/200 dilution.

Western blot - Anti-PEX11B antibody (AB211508)
  • WB

Supplier Data

Western blot - Anti-PEX11B antibody (AB211508)

All lanes:

Western blot - Anti-PEX11B antibody (ab211508) at 1/500 dilution

Lane 1:

MCF-7 cell lysate

Lane 2:

Raw264.7 cell lysate

Lane 3:

PC12 cell lysate

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human PEX11B aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

O96011

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.5 - 7.9 Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX11B or peroxisomal biogenesis factor 11 beta is a protein involved in the maintenance and proliferation of peroxisomes. The protein has a molecular mass of approximately 27 kDa. PEX11B is expressed throughout different tissues but has higher expression levels in tissues with high metabolic activity such as the liver brain and kidneys. This protein belongs to the PEX family which plays a role in peroxisome dynamics.
Biological function summary

PEX11B participates in the elongation and division of peroxisomes. It does not function independently but instead interacts with other peroxisomal biogenesis factors as part of a larger complex responsible for peroxisome morphogenesis. This action is important for maintaining proper peroxisome numbers and adapting cell compartmentalization according to metabolic demands. By affecting peroxisome dynamics PEX11B indirectly influences cellular processes like fatty acid beta-oxidation and reactive oxygen species detoxification.

Pathways

PEX11B's role is significant in the peroxisomal biogenesis pathway facilitating peroxisome multiplication. It connects with other proteins such as DRP1 which assists in membrane fission during division. The coordinated function of these proteins ensures proper peroxisomal turnover and function. Additionally PEX11B influences the cellular response to oxidative stress by regulating peroxisome numbers which in turn impacts cellular signaling pathways involved in stress response.

PEX11B mutations are linked to certain peroxisome biogenesis disorders like Zellweger spectrum disorders. These mutations can lead to impaired peroxisome function resulting in critical metabolic imbalances and developmental issues. PEX11B closely associates with other peroxin proteins such as PEX1 and PEX6 which share roles in peroxisomal assembly. Together they highlight the impact of peroxisome homeostasis on human health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in peroxisomal proliferation (PubMed : 9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed : 12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed : 20826455).
See full target information PEX11B
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:564 PubMed40715045

2025

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.

Applications

Unspecified application

Species

Unspecified reactive species

Li Yang,Xiaoqin An,Shangzhu Yang,Xiaowen Lin,Ziyuan Chen,Qian Xue,Xi Chen,Yuan Wang,Ding Yan,Shirui Chen,Yuqing Fan,Daolin Tang,Wenfeng Yu,Jinbao Liu,Xin Chen

Cell communication and signaling : CCS 22:142 PubMed38383392

2024

TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Laxman Manandhar,Raghbendra Kumar Dutta,Pradeep Devkota,Arun Chhetri,Xiaofan Wei,Channy Park,Hyug Moo Kwon,Raekil Park

Npj viruses 2:6 PubMed40295745

2024

The Wnt/β-catenin pathway is important for replication of SARS-CoV-2 and other pathogenic RNA viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Zaikun Xu,Mohamed Elaish,Cheung Pang Wong,Bardes B Hassan,Joaquin Lopez-Orozco,Alberto Felix-Lopez,Natacha S Ogando,Les Nagata,Lara K Mahal,Anil Kumar,Joyce A Wilson,Ryan Noyce,Irv Mayers,Christopher Power,David Evans,Tom C Hobman
View all publications
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