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AB204841

Anti-PEX13 antibody

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(1 Publication)

Rabbit Polyclonal PEX13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX13 aa 300-400.

View Alternative Names

Peroxisomal membrane protein PEX13, Peroxin-13, PEX13

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-PEX13 antibody (AB204841)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PEX13 antibody (AB204841)

Immunofluorescent analysis of U-2 OS cells labeling PEX13 with ab204841 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX13 antibody (AB204841)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX13 antibody (AB204841)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human rectum tissue labeling PEX13 with ab204841 at 1/50.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PEX13 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q92968

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX13 also called peroxin-13 is a protein involved in peroxisomal biogenesis. This protein has a molecular mass of approximately 42 kDa. PEX13 is expressed mainly in tissues that have a significant peroxisomal content such as the liver and kidney. It forms part of the peroxisome membrane where it facilitates the import of proteins into the peroxisome matrix. This process is essential for maintaining proper peroxisome function which plays a role in lipid metabolism and reactive oxygen species detoxification.
Biological function summary

PEX13 participates in the assembly of the peroxisomal importomer complex a multi-protein structure essential for peroxisomal matrix protein import. PEX13 interacts with other peroxins such as PEX14 and PEX5 to mediate the docking and translocation of cargo proteins that bear peroxisomal targeting signals. This process ensures that proteins required for peroxisomal functions are correctly imported impacting cellular homeostasis.

Pathways

PEX13 plays a role in peroxisome biogenesis and functioning pathways. In the peroxisome biogenesis pathway PEX13 directly interacts with other peroxins like PEX14 to assist in the formation and maintenance of functional peroxisomes. Alongside its interaction with PEX5 PEX13 is important in pathways facilitating the import of enzymes necessary for fatty acid beta-oxidation and hydrogen peroxide detoxification within peroxisomes.

PEX13 mutations are linked to Zellweger spectrum disorders a group of peroxisome biogenesis disorders. These conditions impair normal peroxisomal functions leading to severe developmental and neurological defects. Additionally some cases of neonatal adrenoleukodystrophy have associations with PEX13 dysfunction highlighting its role in peroxisome-related metabolic pathways. The disruption in PEX13 function in these disorders often involves its interactions with proteins such as PEX14 and PEX5 leading to improper protein import and peroxisomal dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed : 28765278, PubMed : 8858165, PubMed : 9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed : 28765278, PubMed : 8858165, PubMed : 9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed : 8858165, PubMed : 9653144).
See full target information PEX13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 12:727915 PubMed34526970

2021

Upregulation of in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control.

Applications

Unspecified application

Species

Unspecified reactive species

Dongxiao Zhang,Satoshi Yamaguchi,Xinhao Zhang,Boxuan Yang,Naoko Kurooka,Ryosuke Sugawara,Haya Hamed H Albuayjan,Atsuko Nakatsuka,Jun Eguchi,Takeshi Y Hiyama,Atsunori Kamiya,Jun Wada
View all publications
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