Rabbit Polyclonal PEX13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PEX13 aa 300-400.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PEX13 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q92968
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:28765278, PubMed:8858165, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:28765278, PubMed:8858165, PubMed:9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:8858165, PubMed:9653144).
Alternative names
Peroxisomal membrane protein PEX13, Peroxin-13, PEX13
Recommended products
Rabbit Polyclonal PEX13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PEX13 aa 300-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PEX13 aa 300-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q92968
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PEX13 also called peroxin-13 is a protein involved in peroxisomal biogenesis. This protein has a molecular mass of approximately 42 kDa. PEX13 is expressed mainly in tissues that have a significant peroxisomal content such as the liver and kidney. It forms part of the peroxisome membrane where it facilitates the import of proteins into the peroxisome matrix. This process is essential for maintaining proper peroxisome function which plays a role in lipid metabolism and reactive oxygen species detoxification.
- Biological function summary
PEX13 participates in the assembly of the peroxisomal importomer complex a multi-protein structure essential for peroxisomal matrix protein import. PEX13 interacts with other peroxins such as PEX14 and PEX5 to mediate the docking and translocation of cargo proteins that bear peroxisomal targeting signals. This process ensures that proteins required for peroxisomal functions are correctly imported impacting cellular homeostasis.
- Pathways
PEX13 plays a role in peroxisome biogenesis and functioning pathways. In the peroxisome biogenesis pathway PEX13 directly interacts with other peroxins like PEX14 to assist in the formation and maintenance of functional peroxisomes. Alongside its interaction with PEX5 PEX13 is important in pathways facilitating the import of enzymes necessary for fatty acid beta-oxidation and hydrogen peroxide detoxification within peroxisomes.
- Associated diseases and disorders
PEX13 mutations are linked to Zellweger spectrum disorders a group of peroxisome biogenesis disorders. These conditions impair normal peroxisomal functions leading to severe developmental and neurological defects. Additionally some cases of neonatal adrenoleukodystrophy have associations with PEX13 dysfunction highlighting its role in peroxisome-related metabolic pathways. The disruption in PEX13 function in these disorders often involves its interactions with proteins such as PEX14 and PEX5 leading to improper protein import and peroxisomal dysfunction.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-PEX13 antibody (ab204841)
Immunofluorescent analysis of U-2 OS cells labeling PEX13 with ab204841 at 4 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX13 antibody (ab204841)
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human rectum tissue labeling PEX13 with ab204841 at 1/50.
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