Rabbit Polyclonal PEX19 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PEX19 aa 1 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PEX19 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P40855
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Predicted | Predicted | Predicted |
| Rat | Predicted | Predicted | Predicted |
| Cow | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/200.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Alternative names
HK33, PXF, OK/SW-cl.22, PEX19, Peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein
Recommended products
Rabbit Polyclonal PEX19 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PEX19 aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PEX19 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P40855
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
Purified by antigen affinity chromatography.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PEX19 also known as peroxisomal biogenesis factor 19 is a protein important for the assembly of peroxisomal membranes. It has a molecular mass of approximately 36 kDa and is expressed across multiple tissues in the human body with particularly high levels in the liver and kidneys. This protein functions as a chaperone and is essential for the import of peroxisomal membrane proteins. It plays a significant role in the binding of these peroxisomal proteins and helps in their transportation to the peroxisomes.
- Biological function summary
The protein plays a central role in peroxisome biogenesis facilitating the correct assembly and maintenance of the peroxisome. PEX19 interacts with other components in the peroxisomal import machinery such as PEX3 and PEX16 forming a complex responsible for the recognition and stabilization of peroxisomal membrane proteins. Through these interactions it ensures the functional integrity of peroxisomes which are important for metabolic tasks like fatty acid beta-oxidation and detoxification of hydrogen peroxide.
- Pathways
PEX19 is involved in the peroxisomal protein import pathway and the broader lipid metabolism pathway. It plays an important role in peroxisomal membrane assembly through its interactions with PEX3 a receptor on the peroxisomal membrane that facilitates protein docking. This process is essential for maintaining efficient peroxisomal functions as disruptions may lead to metabolic imbalances involving lipids and reactive oxygen species.
- Associated diseases and disorders
PEX19 has significant implications in peroxisomal biogenesis disorders including Zellweger spectrum disorders. Mutations or deficiencies in PEX19 can lead to impaired peroxisome formation manifesting in severe metabolic dysfunctions. PEX19 is linked to disorders characterized by neurological deficits liver dysfunction and skeletal abnormalities. Its relationship with PEX3 is also critical in these disorders as any disruptions in their interaction can exacerbate the condition's severity.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-PEX19 antibody (ab95959)
12% SDS PAGE
All lanes: Western blot - Anti-PEX19 antibody (ab95959) at 1/1000 dilution
All lanes: MOLT4 whole cell lysate at 30 µg
Predicted band size: 33 kDa
Immunocytochemistry/ Immunofluorescence - Anti-PEX19 antibody (ab95959)
ab95959, at a 1/200 dilution, staining PEX19 in paraformaldehyde fixed A549 cell by Immunofluorescence analysis.
Image on the right: merged with DNA probe.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX19 antibody (ab95959)
ab95959, at a 1/500 dilution, staining PEX19 in paraffin embedded SW480 xenograft by Immunohistochemistry.
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