JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235084

Anti-PEX26 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal PEX26 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PEX26 aa 1-200.

View Alternative Names

Peroxisome assembly protein 26, Peroxin-26, PEX26

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX26 antibody (AB235084)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX26 antibody (AB235084)

Paraffin-embedded human colon cancer tissue stained for PEX26 using ab235084 at 1/400 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.

Western blot - Anti-PEX26 antibody (AB235084)
  • WB

Supplier Data

Western blot - Anti-PEX26 antibody (AB235084)

All lanes:

Western blot - Anti-PEX26 antibody (ab235084) at 1/500 dilution

All lanes:

K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PEX26 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q7Z412

style
left-column

Complementary Products

Primary Antibodies

AB235043

Anti-PEX13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX13 antibody (AB235043)

  • 0
  • 0
Primary Antibodies

AB17056

Anti-PLK1 antibody [35-206]

Immunocytochemistry - Anti-PLK1 antibody [35-206] (AB17056)

  • 4
  • 6
Primary Antibodies

AB235400

Anti-CSN7A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CSN7A antibody (AB235400)

  • 0
  • 0
Primary Antibodies

AB285367

Anti-ISG15 antibody [EPR24482-49]

BOND RX™ Validated|RabMAb|20ul selling size|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-ISG15 antibody [EPR24482-49] (AB285367)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p>" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX26 also known as Peroxin 26 is a protein critical for peroxisomal function. It has a molecular mass of approximately 33 kDa. PEX26 is localized in the peroxisomal membrane and is mainly expressed in various tissues including liver kidney and brain. Its role is important in the peroxisome import machinery where it anchors the PEX1-PEX6 complex to the peroxisome membrane enabling the transport and maintenance of matrix proteins necessary for peroxisome function.
Biological function summary

The importance of PEX26 lies in its role as part of the peroxisome biogenesis complex. It anchors PEX1 and PEX6 which are essential components for ATPase activity important for peroxisome assembly and function. This tightly regulated process ensures that peroxisomes function correctly in metabolic pathways such as fatty acid β-oxidation and reactive oxygen species detoxification.

Pathways

PEX26 is instrumental in the peroxisomal matrix protein import pathway. This pathway includes the interaction between PEX1 and PEX6 where PEX26 is an anchor within the membrane structure. The pathway's proper function is essential to cellular lipid metabolism and detoxification processes linking it to proteins such as PEX5 that acts as a receptor for matrix proteins targeting peroxisomes.

Defects in PEX26 often associate with peroxisome biogenesis disorders such as Zellweger Spectrum Disorders (ZSD). These disorders result from improper peroxisome function due to mutations in the PEX26 gene leading to various metabolic dysfunctions. PEX26 mutations are especially significant in Zellweger syndrome a severe form of ZSD. The inability to correctly bind PEX1 and PEX6 leads to defective peroxisomal assembly critically impacting cellular health and leading to clinical manifestations associated with these disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118). PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed : 12717447, PubMed : 12851857, PubMed : 16257970, PubMed : 16763195, PubMed : 16854980, PubMed : 21362118).
See full target information PEX26
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 19:1781-1802 PubMed36541703

2022

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas D Demers,Victoria Riccio,Doo Sin Jo,Sushil Bhandari,Kelsey B Law,Weifang Liao,Choy Kim,G Angus McQuibban,Seong-Kyu Choe,Dong-Hyung Cho,Peter K Kim

International journal of laboratory hematology 42:464-472 PubMed32359033

2020

LncRNA MEG3 contributes to drug resistance in acute myeloid leukemia by positively regulating ALG9 through sponging miR-155.

Applications

Unspecified application

Species

Unspecified reactive species

Yanan Yu,Daqing Kou,Bing Liu,Yiran Huang,Shuangda Li,Yu Qi,Yanru Guo,Tong Huang,Xia Qi,Li Jia
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com