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AB247042

Anti-PEX3 antibody

3

(1 Review)

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(1 Publication)

Rabbit Polyclonal PEX3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX3 aa 250 to C-terminus.

View Alternative Names

Peroxisomal biogenesis factor 3, Peroxin-3, Peroxisomal assembly protein PEX3, PEX3

7 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human liver tissue using ab247042 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human thyroid gland tissue using ab247042 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human testis tissue using ab247042 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human kidney tissue using ab247042 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human skeletal muscle using ab247042 at 1/200 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-PEX3 antibody (AB247042)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PEX3 antibody (AB247042)

PFA fixed, Triton X-100 permeabilized A431 (Human epidermoid carcinoma cell line) cells labeling PEX3 using ab247042 at 4 μg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX3 antibody (AB247042)

Immunohistochemical analysis showing PEX3 staining in paraffin embedded Human adrenal gland tissue using ab247042 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PEX3 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P56589

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX3 also known as Peroxisomal biogenesis factor 3 is a protein involved in peroxisome formation. PEX3 has a known amino acid sequence that gives it a molecular mass of approximately 45 kDa. It is mainly expressed in tissues with high metabolic activity such as liver kidney and heart. As a membrane protein PEX3 is located on the peroxisomal membrane and plays a direct role in the import of proteins into the peroxisome.
Biological function summary

PEX3 is essential for the protein import machinery of peroxisomes. It acts as a receptor on the peroxisomal membrane interacting with other peroxisomal proteins including PEX19. This interaction helps in the assembly of peroxisomal membrane proteins. It is part of a larger protein complex necessary for the formation and maintenance of functional peroxisomes which are organelles responsible for various metabolic functions.

Pathways

PEX3 plays a central role in peroxisome biogenesis. It functions within the peroxisomal protein import pathway an important process for the maintenance of peroxisomes. In this context PEX3 interacts closely with PEX19 which acts as a chaperone and receptor for newly synthesized peroxisomal membrane proteins. Together PEX3 and PEX19 facilitate the import and proper localization of these proteins into the peroxisomal membrane.

Mutations or deficiencies in PEX3 can lead to peroxisome biogenesis disorders (PBDs) such as Zellweger syndrome. This severe genetic disorder affects multiple systems and results from impaired peroxisomal formation and function. PEX1 another protein involved in peroxisome biogenesis also relates to these disorders emphasizing the importance of coordinated interactions between these proteins for proper cellular function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
See full target information PEX3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 22:142 PubMed38383392

2024

TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Laxman Manandhar,Raghbendra Kumar Dutta,Pradeep Devkota,Arun Chhetri,Xiaofan Wei,Channy Park,Hyug Moo Kwon,Raekil Park
View all publications
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Product promise

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