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AB167036

Anti-PEX7 antibody

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(2 Publications)

Rabbit Polyclonal PEX7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PEX7.

View Alternative Names

PTS2R, PEX7, Peroxisomal targeting signal 2 receptor, PTS2 receptor, Peroxin-7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX7 antibody (AB167036)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX7 antibody (AB167036)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Breast tissue labeling PEX7 with ab167036 at 5 µg/ml.

Western blot - Anti-PEX7 antibody (AB167036)
  • WB

Unknown

Western blot - Anti-PEX7 antibody (AB167036)

All lanes:

Western blot - Anti-PEX7 antibody (ab167036) at 1/500 dilution

Lane 1:

NIH-3T3 cell extract

Lane 2:

NIH-3T3 cell extract with immunizing peptide

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human PEX7. The exact immunogen used to generate this antibody is proprietary information.

O00628

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEX7 also known as Peroxisomal Biogenesis Factor 7 functions as a receptor for peroxisomal targeting signal 2 (PTS2). PEX7 has a molecular mass of approximately 39 kDa and localizes primarily in the cytoplasm and peroxisomes of cells. It is abundantly expressed in a variety of tissues including the liver kidney and heart. The expression level suggests that PEX7 plays an important mechanical role in peroxisomal import processes.
Biological function summary

PEX7 facilitates the import of peroxisomal matrix proteins with PTS2 signals by forming a complex with them. This complex guides the proteins to the peroxisome important for maintaining peroxisomal function and integrity. PEX7 interacts with other peroxisomal biogenesis factors such as PEX5 and PEX14 during this process. Proper functioning of PEX7 ensures that enzymes needed for lipid metabolism and other peroxisomal activities are correctly imported to their destination.

Pathways

Peroxisomal protein import involves PEX7 which integrates into broader systems like the peroxisome biogenesis and lipid metabolism pathways. In these pathways PEX7 associates with PEX5 an important player in both pathways facilitating the import of important enzymes for beta-oxidation of fatty acids. Without the proper coordination of these proteins the pathways would falter leading to metabolic irregularities.

Malfunction of PEX7 correlates strongly with Rhizomelic Chondrodysplasia Punctata (RCDP) and Zellweger Spectrum Disorders (ZSD). In these conditions PEX7's interaction with proteins like PEX5 becomes compromised leading to impaired peroxisomal protein import and subsequent cellular dysfunction. The dysfunctions highlight the importance of PEX7 in maintaining normal cellular physiology and highlight its relevance in therapeutic research targeting these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed : 11931631, PubMed : 22057399, PubMed : 25538232, PubMed : 9090381). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed : 11931631, PubMed : 22057399, PubMed : 25538232). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed : 11546814, PubMed : 25538232).
See full target information PEX7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 10:886316 PubMed35898397

2022

A Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity-Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1.

Applications

Unspecified application

Species

Unspecified reactive species

Wedad Fallatah,Wei Cui,Erminia Di Pietro,Grace T Carter,Brittany Pounder,Fabian Dorninger,Christian Pifl,Ann B Moser,Johannes Berger,Nancy E Braverman

Clinical and translational medicine 12:e944 PubMed35735113

2022

Lipid metabolism-related lncRNA SLC25A21-AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c-Myc axis and SLC25A21 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Liu,Chunxiang Li,Lingling Fang,Liyu Wang,Hengchang Liu,He Tian,Yujia Zheng,Tao Fan,Jie He
View all publications
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