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AB118603

Anti-PGC1 beta antibody

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(1 Publication)

Goat Polyclonal PGC1 beta antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPARGC1B aa 1-50.

View Alternative Names

PERC, PGC1, PGC1B, PPARGC1, PPARGC1B, Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PPARGC1B aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q86YN6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75-7.5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

This product may be covered by one or more of the following U.S. Patents.

6,166,192
6,426,411
6,525,178
6,872,391
6,908,987
7,250,283
7,091,006
7,354,738
8,105,774
8,445,233

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PGC1 beta also known as PPARGC1B or PERC is an important transcriptional coactivator involved in the regulation of genes related to energy metabolism. It has a molecular weight of approximately 102 kDa. Researchers have found PGC1 beta expressed in various tissues with high metabolic activity including heart skeletal muscle liver and brown adipose tissue. By interacting with numerous nuclear receptors and other transcription factors PGC1 beta modulates the transcription of genes important for mitochondrial biogenesis and function.
Biological function summary

PGC1 beta plays a significant role in the regulation of energy homeostasis and adaptive thermogenesis. It partners with specific DNA-binding proteins as part of large coactivator complexes to enhance transcriptional activity. Essential to maintaining energy balance PGC1 beta facilitates the switch between glucose and fatty acid oxidation in response to metabolic demands. This coactivator's ability to interact with key metabolic regulators such as PPARs and ERRα highlights its vital role in cellular energy regulation.

Pathways

PGC1 beta has an important role in energy metabolism including the oxidative phosphorylation and fatty acid oxidation pathways. It functions closely with PPAR-γ and PPAR-α as well as other proteins like NRF1 and NRF2 to regulate the expression of genes involved in mitochondrial function. PGC1 beta activates these pathways contributing to efficient energy utilization and mitochondrial biogenesis important for adapting to varying energy requirements.

PGC1 beta has associations with metabolic diseases like type 2 diabetes and obesity. Altered expression or function of PGC1 beta can disrupt normal metabolic regulation leading to energy imbalance and insulin resistance. Studies link PGC1 beta modulation to liver disease as well connecting it with proteins such as SIRT1 which also plays a role in metabolic homeostasis and cellular stress responses. Understanding PGC1 beta's involvement in these diseases could provide insights into potential therapeutic approaches for metabolic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
See full target information PPARGC1B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular reproduction and development 92:e70049 PubMed40838423

2025

Three-Dimensional Magnetic Bioprinting Spheroids as an In Vitro Model to Study the Oviductal Physiology.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Kubo Fontes,Ana Beatriz Florencio da Silva,Ana Beatriz Dos Reis Bartoli,Thays Antunes,Arnaldo Rodrigues Dos Santos Júnior,Marcella Pecora Milazzotto
View all publications
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Product promise

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