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AB96159

Anti-PGCP antibody

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Rabbit Polyclonal PGCP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CPQ.

View Alternative Names

LCH1, PGCP, CPQ, Carboxypeptidase Q, Lysosomal dipeptidase, Plasma glutamate carboxypeptidase

1 Images
Western blot - Anti-PGCP antibody (AB96159)
  • WB

Unknown

Western blot - Anti-PGCP antibody (AB96159)

7.5% SDS PAGE

All lanes:

Western blot - Anti-PGCP antibody (ab96159) at 1/500 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 52 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CPQ. The exact immunogen used to generate this antibody is proprietary information.

Q9Y646

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PGCP also known as plasma glutamate carboxypeptidase functions mechanically by catalyzing the cleavage of C-terminal glutamate residues from its substrates. PGCP with a molecular mass approximately 55 kDa is highly expressed in the liver and kidney. Researchers have observed its expression in both human and mouse tissues which implies a conserved role across species. PGCP participates in processes that maintain proper levels of free glutamate an important amino acid in metabolic pathways.
Biological function summary

PGCP modulates the balance of circulating peptides by hydrolyzing carboxy-terminal glutamate. It does not operate as part of a larger protein complex but functions independently. By regulating peptides PGCP helps in processes like protein degradation and recycling. It also influences the bioavailability of certain hormones and metabolites thereby affecting metabolic and signal transduction pathways.

Pathways

PGCP actively partakes in the regulation of blood coagulation and metabolism of amino acids. It interacts with proteins like angiotensin II as it processes bioactive peptides involved in blood pressure regulation. Through these actions PGCP affects the renin-angiotensin system which plays a critical role in cardiovascular health. Additionally PGCP associates with amino acid metabolism pathways where its role in glutamate modulation supports cellular energy production and neurotransmitter synthesis.

PGCP's dysregulation connects it to hypertension and metabolic syndrome. Researchers link altered PGCP activity with imbalances in the renin-angiotensin system leading to increased blood pressure. Furthermore its interaction with proteins like bradykinin influences inflammatory responses and researchers hypothesize its involvement in metabolic syndrome due to its role in amino acid processing. Understanding PGCP's contributions aids in exploring therapeutic interventions for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
See full target information CPQ
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