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AB188758

Anti-PGE2 receptor EP4 subtype antibody

3

(2 Reviews)

|

(1 Publication)

Rabbit Polyclonal PGE2 receptor EP4 subtype antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PTGER4.

View Alternative Names

PTGER2, PTGER4, Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGE2 receptor EP4 subtype antibody (AB188758)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGE2 receptor EP4 subtype antibody (AB188758)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human colon tissue, labeling PGE2 receptor EP4 with ab188758 at 3 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PTGER4. The exact immunogen used to generate this antibody is proprietary information.

P35408

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Alternative Products

Primary Antibodies

AB217966

Anti-PGE2 receptor EP4 subtype antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGE2 receptor EP4 subtype antibody (AB217966)

  • 0
  • 0
Primary Antibodies

AB188761

Anti-PGE2 receptor EP4 subtype antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGE2 receptor EP4 subtype antibody - C-terminal (AB188761)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB167171

Anti-Prostaglandin E Receptor EP2/PTGER2 antibody [EPR8030(B)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody [EPR8030(B)] (AB167171)

  • 5
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105
Primary Antibodies

AB217925

Anti-Prostaglandin E Receptor EP1/PTGER1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-3 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PGE2 receptor EP4 subtype also known as PTGER4 is a member of the G protein-coupled receptor (GPCR) family. This receptor binds prostaglandin E2 and plays a role in various physiological processes. The protein has an approximate mass of 65 kDa. EP4 receptor is widely expressed in tissues such as the immune system bone gastrointestinal tract and reproductive organs indicating its diverse functional implications. Additionally EP4 receptor is activated by PGE2 EP4 agonists which help in modulating its activity.
Biological function summary

EP4 receptor influences numerous functions including inflammation immune response and bone metabolism. The receptor is not part of a larger complex but interacts with different signaling molecules and secondary messengers during its activity. It modulates responses mainly through cAMP which further amplifies or reduces cellular responses depending on the context. These biological roles display the versatile effects EP4 can exert during various physiological scenarios.

Pathways

The EP4 receptor is a significant component in the prostaglandin signaling pathway. This pathway involves the conversion of arachidonic acid to prostaglandin E2 followed by binding to EP4 triggering downstream effects via cAMP-related signals. Within this pathway it interacts closely with proteins like adenylate cyclase which plays a role in regulating cAMP levels. EP4 also participates in the Wnt signaling pathway where it can either enhance or inhibit processes by interacting with other signaling cascade proteins.

EP4 receptor has connections with conditions like rheumatoid arthritis and bone-related diseases. In rheumatoid arthritis excessive signaling through EP4 exacerbates inflammatory responses in joint tissue. The receptor potentially associates with inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) contributing to disease severity. In bone-related diseases such as osteoporosis EP4 influences bone remodeling and homeostasis linking to proteins involved in bone formation and resorption dynamics.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
See full target information PTGER4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 12:897-903 PubMed27446366

2016

Melatonin downregulates nuclear receptor RZR/RORγ expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells and .

Applications

Unspecified application

Species

Unspecified reactive species

Ri-Xiong Wang,Hui Liu,Li Xu,Hui Zhang,Rui-Xiang Zhou
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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