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AB251868

Anti-PGM2 antibody

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(1 Publication)

Rabbit Polyclonal PGM2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PGM2 aa 150-300.

View Alternative Names

MSTP006, PGM2, Phosphopentomutase, Glucose phosphomutase 2, Phosphodeoxyribomutase, Phosphoglucomutase-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGM2 antibody (AB251868)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGM2 antibody (AB251868)

Paraffin-embedded human testis tissue stained for PGM2 using ab251868 at 1/1000 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PGM2 antibody (AB251868)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PGM2 antibody (AB251868)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for PGM2 (green) using ab251868 at 4 µg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PGM2 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q96G03

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Phosphoglucomutase 2 also known as PGM2 is an enzyme involved in carbohydrate metabolism. It catalyzes the reversible conversion of glucose-1-phosphate to glucose-6-phosphate an essential step in glycogenesis and glycogenolysis. PGM2 has a mass of about 65 kDa and is expressed in various tissues including liver muscle and brain. It is often expressed in cells that require significant amounts of energy due to its role in glucose utilization.
Biological function summary

PGM2 functions to maintain cellular energy balance by supporting glycogen storage and breakdown. It operates as an individual enzyme not being part of any multi-enzyme complex but it significantly impacts glucose flux within cells. The enzyme plays a role in both anabolic and catabolic processes highlighting its importance in energy homeostasis. Adequate functioning of PGM2 ensures that cells have access to glucose during fasting or between meals vital for processes like muscle contraction and brain function.

Pathways

PGM2 is actively involved in the glycogen metabolism pathway and interacts with key enzymes like glycogen phosphorylase and glycogen synthase. Its enzymatic activity links it to pathways such as glycolysis where glucose-6-phosphate serves as a substrate. Through its role in glucose conversion PGM2 influences the availability of substrate for additional enzymes in glycolysis and glycogenesis impacting energy production and storage in cells.

Defects in PGM2 have been associated with glycogen storage disease which affects glucose and glycogen metabolism leading to energy production issues. It is also observed in metabolic myopathies where disordered energy metabolism leads to muscle weakness and fatigue. PGM2 interacts with glycogen phosphorylase in these disorders as both play parts in the conversion of glucose-1-phosphate to glucose-6-phosphate implicating their coordination in maintaining metabolic stability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed : 17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed : 17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed : 17804405). In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed : 17804405, PubMed : 18927083).
See full target information PGM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e35303 PubMed39170313

2024

ITPKA phosphorylates PYCR1 and promotes the progression of glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangying Luo,Tao Chen,Junyi Deng,Ziyuan Liu,Changlong Bi,Song Lan
View all publications
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Product promise

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