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AB13903

Anti-PGRPS antibody [188C424]

5

(1 Review)

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(1 Publication)

Mouse Monoclonal PGRPS antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PGLYRP1 aa 150 to C-terminus.

View Alternative Names

PGLYRP, PGRP, TNFSF3L, SBBI68, UNQ639/PRO1269, PGLYRP1, Peptidoglycan recognition protein 1, Peptidoglycan recognition protein short, PGRP-S

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGRPS antibody [188C424] (AB13903)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGRPS antibody [188C424] (AB13903)

Immunocytochemistry analysis of human esophagus cells labelling PGRPS with ab13903 at 20 μg/mL. The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Staining of peripheral leukocytes and neutrophils was observed. Staining was performed by Histowiz.

Western blot - Anti-PGRPS antibody [188C424] (AB13903)
  • WB

Unknown

Western blot - Anti-PGRPS antibody [188C424] (AB13903)

All lanes:

Western blot - Anti-PGRPS antibody [188C424] (ab13903) at 2 µg/mL

All lanes:

Jurkat cell lysate

Predicted band size: 22 kDa

Observed band size: 28 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

188C424

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human PGLYRP1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O75594

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Peptidoglycan Recognition Proteins (PGRPs) are pattern recognition receptors known for their role in innate immunity. Some alternate names for PGRPs include PGLYRPs. These proteins identify bacterial peptidoglycans triggering immune responses. PGRPs have varying molecular masses that range typically between 20 to 25 kDa. Expression of PGRPs occurs in several tissues including skin eyes liver and throughout the gastrointestinal tract.
Biological function summary

Functioning in innate immunity PGRPs bind to bacterial cell wall components such as peptidoglycan and lipopolysaccharides. When PGRPs detect these molecules they can activate immune responses to neutralize pathogens. Some PGRPs can also act as amidases breaking down peptidoglycans. PGRPs do not usually act alone; they are part of complexes with other immune proteins to enhance pathogen recognition and response.

Pathways

PGRPs play significant roles in the immune pathway and inflammatory signaling pathways. They interact with the toll-like receptor pathways to mediate responses to bacterial infections. PGRPs also link with Nod proteins to modulate the immune response upon detecting peptidoglycans. These pathways help coordinate an effective defense against infection.

PGRPs’ malfunction or dysregulation links with inflammatory bowel disease and psoriasis. Altered PGRP levels correlate with changes in the gut flora contributing to inflammatory bowel disease. In psoriasis PGRPs’ improper function may exacerbate skin inflammation because they interact with proteins like IL-6 and TNF-alpha. Such interactions highlight their potential as therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed : 9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed : 21247889, PubMed : 26183779). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed : 26654597). Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed : 30713770). Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed : 28977785, PubMed : 29083508). Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed : 25595774, PubMed : 28977785).
See full target information PGLYRP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of inflammation (London, England) 13:36 PubMed27932936

2016

Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls infection by boosting murine macrophage function and regulates inflammation.

Applications

IF

Species

Unspecified reactive species

Somrita Dey,Biswadev Bishayi
View all publications
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