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AB118190

Anti-PHF20L1 antibody

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(2 Publications)

Rabbit Polyclonal PHF20L1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PHF20L1 aa 700 to C-terminus.

View Alternative Names

CGI-72, PHF20L1, PHD finger protein 20-like protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PHF20L1 antibody (AB118190)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PHF20L1 antibody (AB118190)

ab118190, at 1/100 dilution, staining PHF20L1 in formalin-fixed, paraffin-embedded Human fetal brain tissue, by Immunohistochemistry.

Western blot - Anti-PHF20L1 antibody (AB118190)
  • WB

Unknown

Western blot - Anti-PHF20L1 antibody (AB118190)

All lanes:

Western blot - Anti-PHF20L1 antibody (ab118190) at 1/500 dilution

All lanes:

HepG2 cell lysate

Predicted band size: 115 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PHF20L1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

A8MW92

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PHF20L1 also known as Plant Homeodomain Finger Protein 20-Like 1 is involved in chromatin-mediated gene expression regulation. This protein is significant due to its role in reading specific histone marks facilitating proper chromatin remodeling. PHF20L1 has a molecular weight of approximately 110 kDa and is expressed in various tissues such as the heart and skeletal muscle. Its presence in these tissues suggests an important role in muscle function and cellular processes.
Biological function summary

PHF20L1 plays a role in epigenetic regulation and transcriptional silencing. It forms part of chromatin-modifying complexes that influence gene expression by altering chromatin structure. By engaging in these complexes PHF20L1 contributes to the regulation of genes important for cell growth and differentiation. It interacts with other epigenetic regulators to maintain cellular homeostasis indicating its role in gene expression dynamics.

Pathways

PHF20L1 interacts within epigenetic pathways that influence transcriptional control and gene expression regulation. It associates with other proteins such as histone methyltransferases impacting the histone modification pathway. This interaction is essential in maintaining proper cell cycle progression and growth linking it to pathways like the Wnt signaling cascade. These pathways highlight the protein's involvement in transcription regulation processes.

PHF20L1 has been connected to developmental disorders and certain cancers. Alteration in its function or expression may lead to improper gene silencing contributing to oncogenesis. Studies associate PHF20L1 with proteins such as p53 a known tumor suppressor indicating its potential role in maintaining genomic stability. Understanding its involvement in these diseases can provide insights into therapeutic targets for related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed : 24492612, PubMed : 29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity).
See full target information PHF20L1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

General physiology and biophysics 40:17-29 PubMed33655888

2021

circCUX1 promotes neuroblastoma progression and glycolysis by regulating the miR-338-3p/PHF20 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Wang,Qin Niu,Jie Dai,Haitang Shi,Jinzhi Zhang

Molecular and cellular biology 33:2988-95 PubMed23716593

2013

Telomere length influences cancer cell differentiation in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Kyotaro Hirashima,Toshiro Migita,Shigeo Sato,Yukiko Muramatsu,Yuichi Ishikawa,Hiroyuki Seimiya
View all publications
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