Anti-Phospho - (Ser/Thr) antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Phosphorylation on serine and threonine is critical for enabling proteins to participate in various signaling cascades. These phosphorylation sites often form part of larger protein complexes where they serve as regulatory sites for modifying protein activity. Such modifications can impact a protein's role in processes like cell cycle regulation transcription and cellular metabolism. Phospho-serine and phospho-threonine residues influence the structural conformation of proteins affecting their interaction with other cellular components.

Pathways

These phosphorylated residues play a vital role in signaling pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are important for transmitting signals from receptors on the cell surface to the DNA in the nucleus impacting gene expression and cellular responses. Proteins like Protein Kinase A (PKA) and Protein Kinase B (AKT) are often involved in these pathways directly interacting with phosphorylated serine and threonine residues to mediate cellular effects.