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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal Phospho1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PHOSPHO1.
IgG
Rabbit
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Mouse | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes - |
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
Phosphoethanolamine/phosphocholine phosphatase, PHOSPHO1
Rabbit Polyclonal Phospho1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PHOSPHO1.
Phosphoethanolamine/phosphocholine phosphatase, PHOSPHO1
IgG
Rabbit
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Protein G
Purity >95%.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Phospho1 contributes to the mineralization process in bone and cartilage tissue. It plays an integral role in providing inorganic phosphate necessary for hydroxyapatite crystal formation an essential component of the mineral matrix. Phospho1 functions independently although its activity aligns with other enzymes and proteins involved in the mineralization process indicating its singular yet important enzymatic action in this biological context.
Phospho1 also known as PHOSPHO1 is a phosphatase with a molecular weight of approximately 32 kDa. It exhibits high phosphatase activity specific to phosphoethanolamine and phosphocholine. The enzyme localizes mainly in the ossification centers of developing bones particularly in osteoblasts and chondrocytes reflecting its significant role in skeletal mineralization.
Phospho1 is directly involved in the skeletal development and bone mineralization pathways. It interacts closely within the matrix vesicle-mediated mineralization pathway. One notable related protein is alkaline phosphatase which cooperates to supply phosphate ions for matrix mineralization. This collaboration ensures effective hydroxyapatite crystal deposition thereby maintaining bone integrity and function.
Phospho1 associates closely with conditions such as hypophosphatasia and osteoporosis. Its malfunction or dysregulation can cause impaired skeletal mineralization leading to these bone-related ailments. In the context of these conditions Phospho1 activity is linked to alkaline phosphatase as perturbation in either enzyme can result in altered bone mineral density and defective bone mineralization highlighting their collective importance in maintaining skeletal health.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Paraffin-embedded human heart tissue stained for Phospho1 using ab224724 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human kidney tissue stained for Phospho1 using ab224724 at 1/100 dilution in immunohistochemical analysis.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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