Anti-Phospholipase C beta 2/PLCB2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PLCB2 regulates important cellular functions by acting as an important mediator in signaling pathways that rely on G-protein-coupled receptors (GPCRs). It does not operate as part of a larger complex but interacts with G-proteins directly to propagate signals from the cell surface to the intracellular environment. This function establishes PLCB2 as an essential component in transmitting signals that control cell growth differentiation and more specialized activities in certain cell types.

Pathways

PLCB2's role is essential in both the phosphoinositide signaling and calcium signaling pathways. These pathways facilitate various physiological processes including muscle contraction secretion metabolism and others. In the phosphoinositide pathway PLCB2 cooperates closely with G-alpha-q proteins to propagate signals while in calcium signaling it helps modulate the release of calcium ions that activate many downstream proteins such as protein kinase C (PKC).