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AB97751

Anti-Phospholipase c eta 1 antibody

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(2 Publications)

Rabbit Polyclonal Phospholipase c eta 1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLCH1 aa 1-300.

View Alternative Names

KIAA1069, PLCL3, PLCH1, Phosphoinositide phospholipase C-eta-1, Phospholipase C-eta-1, Phospholipase C-like protein 3, PLC-eta-1, PLC-L3

1 Images
Western blot - Anti-Phospholipase c eta 1 antibody (AB97751)
  • WB

Unknown

Western blot - Anti-Phospholipase c eta 1 antibody (AB97751)

5% SDS PAGE

All lanes:

Western blot - Anti-Phospholipase c eta 1 antibody (ab97751) at 1/500 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 189 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PLCH1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q4KWH8

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Phospholipase C eta 1 (PLCη1) also known as PLCN1 is an enzyme that plays an important role in phospholipid signaling pathways. It specifically hydrolyzes phosphatidylinositol 45-bisphosphate (PIP2) into two important second messengers diacylglycerol (DAG) and inositol trisphosphate (IP3). The enzyme has a molecular mass of approximately 126 kDa. Expression of PLCη1 occurs mainly in the brain and nervous tissue highlighting its significant role in the nervous system's function and signaling processes.
Biological function summary

Phospholipase C eta 1 acts as a mediator of intracellular signal transduction. It participates in the regulation of ion channel activity by modulating calcium release from intracellular stores an important function in neural communication. Although not part of a classical multi-protein complex PLCη1 interacts with different signaling molecules and receptors influencing various signaling pathways. This regulatory control of calcium signaling underlies several physiological processes particularly in neurons.

Pathways

Phospholipase C eta 1 engages in the inositol phosphate pathway and the phosphatidylinositol signaling system. Its activity in these pathways leads to the generation of secondary messengers that mediate various downstream effects primarily through interactions with other key proteins including protein kinase C (PKC) and calcium channels. These pathways are critical for controlling neural signaling and plasticity therefore impacting neuron function and communication.

Phospholipase C eta 1 shows a connection with neurological disorders like epilepsy due to its pivotal role in regulating neuronal excitability and calcium signaling. Abnormalities in PLCη1 function or expression levels might relate to the pathophysiology of such disorders. Additionally alterations in PLCη1 are also associated with certain mood disorders given its involvement in neurotransmitter-junction signaling and synaptic plasticity. Studies often link it to disruptions in calcium regulation together with other targets such as G-protein coupled receptors.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
See full target information PLCH1

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental & molecular medicine 57:872-887 PubMed40204881

2025

Role of phospholipase Cη1 in lateral habenula astrocytes in depressive-like behavior in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Sukwoon Song,Miseon Kang,Jiyoung Lee,Yong Ryoul Yang,Ho Lee,Jae-Ick Kim,Beomsue Kim,Hoon-Seong Choi,Eun-Bin Hong,Min-Ho Nam,Pann-Ghill Suh,Jeongyeon Kim

Translational cancer research 9:2721-2733 PubMed35117631

2020

IL-1β secreted by macrophage M2 promotes metastasis of osteosarcoma via NF-κB/miR-181α-5p/RASSF1A/Wnt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Peng Han,Dong-Biao Liu,Liu-Qing Wu,Qin Li,Zheng-Guang Wang,Xiao-Fang Zang
View all publications

Product promise

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