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AB36624

Anti-PI-9 antibody [PI9-17]

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(2 Publications)

Mouse Monoclonal PI-9 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SERPINB9.

View Alternative Names

PI9, SERPINB9, Serpin B9, Cytoplasmic antiproteinase 3, Peptidase inhibitor 9, CAP-3, CAP3, PI-9

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PI9-17

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SERPINB9.

P50453

Specificity

Ab36624 recognises Proteinase Inhibitor 9, as well as Proteinase Inhibitor 9 complexed to granzyme B. It shows no cross reactivity with other homologous serpins (PI6, PI8 and PAI2) was observed.

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Alternative Products

Primary Antibodies

AB150400

Anti-PI-9 antibody [EPR8186(2)]

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Western blot - Anti-PI-9 antibody [EPR8186(2)] (AB150400)

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Primary Antibodies

AB233443

Anti-PI-9 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PI-9 antibody (AB233443)

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Complementary Products

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Anti-Granzyme B antibody [EPR22645-206]

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Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

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Primary Antibodies

AB237709

Anti-CD8 alpha antibody [CAL66]

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Primary Antibodies

AB137588

Anti-SerpinB2/PAI-2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SerpinB2/PAI-2 antibody (AB137588)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: 0.7% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PI-9 protein also known as serpinB9 is a serine protease inhibitor with a molecular mass of approximately 42 kDa. It is expressed primarily in immune cells such as cytotoxic T lymphocytes and natural killer cells as well as in some neurons and hepatocytes. The protein inhibits proteolytic enzymes to prevent unwanted cell death mainly controlling granzyme B activity.
Biological function summary

PI-9 helps regulate immune cell activity and prevent autoimmunity by inhibiting granule-mediated apoptosis. It functions as part of a complex that manages cell death pathways acting as a guardian against excessive cytotoxic actions by the immune system. Its regulatory role ensures the balance between attacking pathogens and protecting host cells from unnecessary destruction.

Pathways

PI-9 plays an integral role in the apoptotic pathway interacting with proteins like granzyme B to protect host cells from immune-mediated killing. It is also involved in the cellular response to stress especially within the immune system's cytotoxic responses. The protein's interaction with granzyme B highlights its role in maintaining the balance between immune defense and cellular protection.

PI-9 has been linked to autoimmune conditions and cancer. It helps regulate autoimmune responses by preventing excessive apoptosis which could otherwise lead to tissue damage. In cancer PI-9 overexpression is sometimes observed potentially allowing tumor cells to evade immune surveillance. The relationship between PI-9 and granzyme B is important in understanding its dual role in disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Granzyme B inhibitor.
See full target information SERPINB9
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncoimmunology 11:2139074 PubMed36465485

2022

is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response.

Applications

Unspecified application

Species

Unspecified reactive species

Sofía Ibáñez-Molero,Alex van Vliet,Joanna Pozniak,Karlijn Hummelink,Alexandra M Terry,Kim Monkhorst,Joyce Sanders,Ingrid Hofland,Ewout Landeloos,Yannick Van Herck,Oliver Bechter,Thomas Kuilman,Weiwei Zhong,Jean-Christophe Marine,Lodewyk Wessels,Daniel S Peeper

Journal of immunology (Baltimore, Md. : 1950) 187:2252-60 PubMed21795594

2011

The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells.

Applications

Unspecified application

Species

Human

Najib El Haddad,Robert Moore,Dean Heathcote,Marwan Mounayar,Jamil Azzi,Bechara Mfarrej,Ibrahim Batal,Christopher Ting,Mark Atkinson,Mohamed H Sayegh,Philip G Ashton-Rickardt,Reza Abdi
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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