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AB192540

Anti-PI3R6 antibody

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(2 Publications)

Rabbit Polyclonal PI3R6 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PIK3R6.

View Alternative Names

C17orf38, PIK3R6, Phosphoinositide 3-kinase regulatory subunit 6, Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, p84 PI3K adapter protein, p87 PI3K adapter protein, p84 PIKAP, p87PIKAP

1 Images
Western blot - Anti-PI3R6 antibody (AB192540)
  • WB

Supplier Data

Western blot - Anti-PI3R6 antibody (AB192540)

All lanes:

Western blot - Anti-PI3R6 antibody (ab192540)

Lane 1:

HepG2 whole cell lysate

Lane 2:

mouse brain tissue lysate

Lane 3:

rat brain tissue lysate

Predicted band size: 84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PIK3R6. The exact immunogen used to generate this antibody is proprietary information.

Q5UE93

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192540 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PI3R6 also known as PI3K gamma regulatory subunit 6 is part of the phosphoinositide 3-kinase (PI3K) family. This protein acts as a regulatory subunit that plays important mechanical role by modulating the catalytic activity of the PI3K gamma complex. PI3R6 is coded by the PIK3R6 gene and has a molecular mass of approximately 87 kilodaltons. Expression of PI3R6 occurs in varying levels across several tissues with elevated levels noted in immune cells and the cardiovascular system.
Biological function summary

PI3R6 contributes to cellular signaling processes particularly those that dictate cell growth proliferation and survival. It forms a complex with the catalytic subunit of the PI3K gamma known as p110 gamma. This regulatory subunit coordinates the localization and activity of the catalytic subunit which in turn converts phosphatidylinositol (45)-bisphosphate (PIP2) to phosphatidylinositol (345)-trisphosphate (PIP3) a critical secondary messenger involved in signal transduction pathways.

Pathways

PI3R6 plays an integral role in the PI3K/AKT signaling pathway which is central to many cellular processes like metabolism growth and survival. Within this pathway it closely interacts with proteins such as AKT1. Additionally PI3R6 is also involved in the immune response through the regulation of leukocyte chemotaxis and integrin-dependent cell migration which it performs by influencing the signaling functions of G protein-coupled receptors (GPCRs).

The dysregulation of PI3R6 activity has been associated with cancers and inflammatory diseases. PI3R6 shows pathological interactions with proteins like mTOR as it can lead to aberrant signaling that promotes tumor growth and proliferation. In inflammatory diseases the misregulation of PI3R6-related pathways can contribute to autoimmune conditions due to its role in immune cell signaling and migration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG : PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG : PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B : RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
See full target information PIK3R6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell adhesion & migration 18:1-12 PubMed38831518

2024

Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Yang,Xiaoni Zhong,Xiaoling Gao,Wenyi Xie,Yaokai Chen,Yuanjiang Liao,Peilin Zhang

The Journal of clinical investigation 132: PubMed36326820

2022

SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Dibyendu K Panda,Xiuying Bai,Yan Zhang,Nicholas A Stylianesis,Antonis E Koromilas,Mark L Lipman,Andrew C Karaplis
View all publications
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