Anti-PIGA antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PIGA facilitates the early steps of GPI anchor formation where it acts as part of a multi-protein complex including PIGC PIGH and PIGP. This complex catalyzes the transfer of N-acetylglucosamine to phosphatidylinositol initiating GPI anchor assembly. The absence or defect of PIGA disrupts GPI anchor biosynthesis affecting the delivery and function of GPI-anchored proteins important for cell signaling cell adhesion and enzyme functions.

Pathways

PIGA's role is important in the early stages of the GPI biosynthetic pathway interconnected with the ER-associated degradation pathway (ERAD). Within these pathways PIGA interacts with proteins such as PIGM and PIGX orchestrating sequential enzymatic reactions and ensuring successful GPI anchor synthesis. These pathways later impact various cellular processes including protein traffic and membrane organization.