Rabbit Polyclonal PIGN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIGN aa 1-200.
View Alternative Names
MCD4, PIGN, GPI ethanolamine phosphate transferase 1, MCD4 homolog, Phosphatidylinositol-glycan biosynthesis class N protein, PIG-N
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIGN antibody (AB238577)
Paraffin-embedded human endometrial cancer tissue stained for PIGN using ab238577 at 1/200 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Reactivity data
Properties and storage information
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Purification notes
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Aliquoting information
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Supplementary information
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Biological function summary
PIGN plays an important role in anchoring proteins to the cell membrane by forming part of the GPI transamidase complex. This complex which includes other proteins such as PIGK PIGS and GPAA1 is essential for the attachment of GPI anchors to proteins. PIGN ensures correct positioning and functionality of proteins on the cell surface affecting cell-cell communication and signaling.
Pathways
PIGN participates in the GPI-anchor biosynthesis pathway. This pathway is important for the surface display of many proteins influencing processes like immune response and signal transduction. PIGN's role is tied to the trafficking and localization of GPI-anchored proteins. It also interacts with proteins like PIGA in the same biosynthetic pathway maintaining the integrity and function of cell membranes.
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Target data
Publications (1)
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Immunity, inflammation and disease 11:e1022 PubMed37904707
2023
Applications
Unspecified application
Species
Unspecified reactive species
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