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AB231122

Anti-PIK3C2B antibody

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(3 Publications)

Rabbit Polyclonal Pik3c2b antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 3 publications.

View Alternative Names

C2 PI3K, P3C2B_HUMAN, PI3K-C2-beta, PTDINS-3-kinase C2 beta, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, Phosphoinositide 3-Kinase class 2, beta, Phosphoinositide 3-Kinase-C2-beta, PtdIns-3-kinase C2 subunit beta, phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, phosphoinositide-3-kinase, class 2, beta polypeptide

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIK3C2B antibody (AB231122)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIK3C2B antibody (AB231122)

Formalin-fixed, paraffin-embedded rat lymph node tissue stained for PIK3C2B using ab231122 at 20 μg/ml in immunohistochemical analysis.

Western blot - Anti-PIK3C2B antibody (AB231122)
  • WB

Supplier Data

Western blot - Anti-PIK3C2B antibody (AB231122)

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Western blot - Anti-PIK3C2B antibody (ab231122) at 1 µg/mL

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Rat serum

Predicted band size: 185 kDa

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Western blot - Anti-PIK3C2B antibody (AB231122)
  • WB

Supplier Data

Western blot - Anti-PIK3C2B antibody (AB231122)

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Western blot - Anti-PIK3C2B antibody (ab231122) at 2 µg/mL

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Recombinant rat PIK3C2B protein

Predicted band size: 185 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231122 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PIK3C2B also known as phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is a type II phosphoinositide 3-kinase with a molecular mass of approximately 187 kDa. This enzyme is part of the PI3K family which plays essential roles in cell signaling pathways. PIK3C2B is mostly present in human tissues such as the liver heart and brain where it functions in various physiological processes. In terms of structure it possesses both a C2 domain aiding in cell membrane interaction and a helical domain that assists in catalysis.
Biological function summary

The enzyme phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide plays a significant role in the regulation of endosomal trafficking and cell migration by phosphorylating phosphoinositides. PIK3C2B can also impact insulin signaling and GLUT4 translocation in cells contributing to glucose metabolism. It forms part of a larger protein complex that aids its action in cellular environments. Its interactions with small GTPases suggest that it is involved in cellular morphology and dynamics.

Pathways

Phosphoinositide-4-phosphate 3-kinase functions significantly in the PI3K/Akt signaling pathway affecting cellular growth and survival. It also plays a role in the insulin signaling pathway where it works alongside proteins like PIK3CA and PTEN in regulating cellular responses to hormones. Through the PI3K/Akt pathway PIK3C2B modulates vital processes such as the cell cycle and apoptosis highlighting its contribution to maintaining cellular homeostasis and response to external signals.

The enzyme phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide associates with metabolic disorders and cancers. Alterations in its expression or function can lead to aberrant signaling in insulin resistance conditions like type 2 diabetes. Additionally due to its role in cell proliferation pathways PIK3C2B induces oncogenic processes when dysregulated. Connections with proteins such as Akt and mTOR further emphasize its relevance in these diseases offering potential therapeutic targets for intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Pik3c2b
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:253 PubMed40618046

2025

Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Hai Jiang,Zhipeng Xu,Qi Song,Junjie Tao,Jia Liu,Qiang Wang,Huaisheng Zhang,Heng Zhu,Qiliang Li,Lei Li

OncoTargets and therapy 13:8299-8311 PubMed32903879

2020

Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Liu,Xiao Li,Jie Ma,Dechuan Li,Haixing Ju,Yong Liu,Yinbo Chen,Xujun He,Yuping Zhu

Frontiers in oncology 10:931 PubMed32695668

2020

Novel Potential Biomarkers Associated With Epithelial to Mesenchymal Transition and Bladder Cancer Prognosis Identified by Integrated Bioinformatic Analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Chengyuan Wang,Yujing Yang,Lei Yin,Ningde Wei,Ting Hong,Zuyu Sun,Jiaxi Yao,Zhi Li,Tao Liu
View all publications
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