Anti-Pinkbar antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein known as Pinkbar alternatively termed F-BAR domain containing 1 (F-BAR1) plays a mechanical role in membrane curvature modulation. Pinkbar is distinguished by its unique ability to form flat membrane protrusions unlike its BAR domain-containing relatives that create tubular structures. The protein has an approximate mass of 35 kDa and expresses widely with significant levels in intestinal epithelial cells. Its interaction with the actin cytoskeleton suggests a role in structural cell processes.

Biological function summary

Pinkbar influences the organization of the cell membrane and cytoskeletal dynamics. It integrates into membrane remodeling activities facilitating alterations in cell shape and motility. Pinkbar also participates as part of a larger protein complex that coordinates actin filament assembly. By binding to phospholipids and interacting with other cytoskeletal proteins Pinkbar conducts changes essential for cellular mechanical stability and communication.

Pathways

Pinkbar merges into cellular processes involving the actin cytoskeleton and the endocytosis pathway. The protein's performance in these pathways ensures efficient membrane-trafficking events and cell motility regulation. Pinkbar collaborates with proteins like actin and cortactin reinforcing the structural framework necessary for the upkeep of cellular architecture and endocytic functionality.

Associated diseases and disorders

Pinkbar connects to conditions like intestinal inflammation and colorectal cancer. Its function in maintaining epithelial cell integrity underpins its role in disease; irregular activity can result in tissue damage or cancer progression. In intestinal inflammation Pinkbar interacts with proteins such as E-cadherin where disruptions in these interactions lead to compromised cell adhesion and increased disease susceptibility.