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Rabbit Polyclonal PINX1/LPTS antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PINX1/LPTS antibody (AB217960), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q96BK5

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Predicted
Mouse
Tested
Rat
Predicted

Tested
Tested

Species

Mouse

Dilution info

1/100.00000 - 1/500.00000

Notes

-

Predicted
Predicted

Species

Rat, Human

Dilution info

-

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.

Alternative names

Recommended products

Rabbit Polyclonal PINX1/LPTS antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q96BK5
Purification technique

Affinity purification Protein A

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PINX1 also known as LPTS is a nuclear protein known for its role as a telomerase inhibitor. It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues including the heart liver and brain. PINX1/LPTS plays an important mechanical role in maintaining the stability of chromosomal ends by binding to telomerase and its components within the nucleus.

Biological function summary

PINX1/LPTS serves as a regulatory factor that ensures genomic integrity by directly inhibiting telomerase. It is not confirmed part of a specific large protein complex but its interaction with telomerase suggests it functions closely within a group of regulatory proteins. Its activity contributes to cell cycle regulation particularly influencing cellular senescence and apoptosis by controlling telomere length.

Pathways

The role of PINX1/LPTS in telomerase inhibition places it in the context of telomeric maintenance and regulation pathways. It closely associates with proteins such as hTERT the catalytic subunit of telomerase and influences the shelterin complex pathways which protect telomeres from being recognized as DNA damage. This positioning emphasizes its involvement in regulating cell aging and proliferation pathways.

Associated diseases and disorders

PINX1/LPTS's involvement in telomere length regulation connects it to conditions like cancer where telomerase activity commonly increases. Altered function of PINX1 has been observed in several cancer types influencing tumor growth and progression. Additionally dysregulation of telomere maintenance in which PINX1 plays a part also links it to disorders like dyskeratosis congenita a condition marked by abnormal telomere shortening.

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PINX1/LPTS antibody (ab217960), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PINX1/LPTS antibody (ab217960)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse kidney tissue labeling PINX1/LPTS with ab217960 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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