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AB217960

Anti-PINX1/LPTS antibody

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Rabbit Polyclonal PINX1/LPTS antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

LPTL, LPTS, PINX1, PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PINX1/LPTS antibody (AB217960)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PINX1/LPTS antibody (AB217960)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse kidney tissue labeling PINX1/LPTS with ab217960 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96BK5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100.00000 - 1/500.00000", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PINX1 also known as LPTS is a nuclear protein known for its role as a telomerase inhibitor. It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues including the heart liver and brain. PINX1/LPTS plays an important mechanical role in maintaining the stability of chromosomal ends by binding to telomerase and its components within the nucleus.
Biological function summary

PINX1/LPTS serves as a regulatory factor that ensures genomic integrity by directly inhibiting telomerase. It is not confirmed part of a specific large protein complex but its interaction with telomerase suggests it functions closely within a group of regulatory proteins. Its activity contributes to cell cycle regulation particularly influencing cellular senescence and apoptosis by controlling telomere length.

Pathways

The role of PINX1/LPTS in telomerase inhibition places it in the context of telomeric maintenance and regulation pathways. It closely associates with proteins such as hTERT the catalytic subunit of telomerase and influences the shelterin complex pathways which protect telomeres from being recognized as DNA damage. This positioning emphasizes its involvement in regulating cell aging and proliferation pathways.

PINX1/LPTS's involvement in telomere length regulation connects it to conditions like cancer where telomerase activity commonly increases. Altered function of PINX1 has been observed in several cancer types influencing tumor growth and progression. Additionally dysregulation of telomere maintenance in which PINX1 plays a part also links it to disorders like dyskeratosis congenita a condition marked by abnormal telomere shortening.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
See full target information PINX1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB190252

Anti-PINX1/LPTS antibody

primary-antibodies

pinx1-lpts-antibody-ab190252

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