Rabbit Polyclonal PINX1/LPTS antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Predicted |
Mouse | Tested |
Rat | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Human | Dilution info - | Notes - |
Select an associated product type
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
LPTL, LPTS, LPTS, LPTL, PINX1, PIN2/TERF1-interacting telomerase inhibitor 1, Liver-related putative tumor suppressor, Pin2-interacting protein X1, Protein 67-11-3, TRF1-interacting protein 1
Rabbit Polyclonal PINX1/LPTS antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human PINX1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
PINX1 also known as LPTS is a nuclear protein known for its role as a telomerase inhibitor. It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues including the heart liver and brain. PINX1/LPTS plays an important mechanical role in maintaining the stability of chromosomal ends by binding to telomerase and its components within the nucleus.
PINX1/LPTS serves as a regulatory factor that ensures genomic integrity by directly inhibiting telomerase. It is not confirmed part of a specific large protein complex but its interaction with telomerase suggests it functions closely within a group of regulatory proteins. Its activity contributes to cell cycle regulation particularly influencing cellular senescence and apoptosis by controlling telomere length.
The role of PINX1/LPTS in telomerase inhibition places it in the context of telomeric maintenance and regulation pathways. It closely associates with proteins such as hTERT the catalytic subunit of telomerase and influences the shelterin complex pathways which protect telomeres from being recognized as DNA damage. This positioning emphasizes its involvement in regulating cell aging and proliferation pathways.
PINX1/LPTS's involvement in telomere length regulation connects it to conditions like cancer where telomerase activity commonly increases. Altered function of PINX1 has been observed in several cancer types influencing tumor growth and progression. Additionally dysregulation of telomere maintenance in which PINX1 plays a part also links it to disorders like dyskeratosis congenita a condition marked by abnormal telomere shortening.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse kidney tissue labeling PINX1/LPTS with ab217960 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
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