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AB127563

Anti-PITPNB antibody

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(1 Publication)

Rabbit Polyclonal PITPNB antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PITPNB aa 1-250.

View Alternative Names

Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNB antibody (AB127563)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNB antibody (AB127563)

ab127563 at 1/500 dilution staining PITPNB in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.

Western blot - Anti-PITPNB antibody (AB127563)
  • WB

Unknown

Western blot - Anti-PITPNB antibody (AB127563)

12% SDS PAGE

All lanes:

Western blot - Anti-PITPNB antibody (ab127563) at 1/1000 dilution

All lanes:

Jurkat whole cell lysate at 30 µg

Predicted band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PITPNB aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P48739

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Complementary Products

Proteins & Peptides

AB101091

Recombinant Human PITPNB protein

SDS-PAGE - Recombinant Human PITPNB protein (AB101091)

  • 0
  • 0
Secondary Antibodies

AB125912

Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L

RabMAb|Recombinant

ELISA - Rabbit monoclonal [H26-10] Anti-Human IgG1 H&L (AB125912)

  • 0
  • 0
Primary Antibodies

AB96551

Anti-MAP4K5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAP4K5 antibody (AB96551)

  • 4
  • 1
Primary Antibodies

AB18207

Anti-beta III Tubulin antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody - Neuronal Marker (AB18207)

  • 5
  • 67
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Aternatively Tris-EDTA buffer (pH8.0) may be used</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Product details

Store undiluted.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PITPNB also known as phosphatidylinositol transfer protein beta isoform plays a role mechanically in lipid transfer between membranes. It weighs around 32 kDa. You can find this protein expressed in various tissues including the brain liver and lungs. PITPNB facilitates lipid metabolism and signaling by transferring phosphatidylinositol and phosphatidylcholine between membranes.
Biological function summary

PITPNB ensures the proper distribution of lipids within cells for membrane composition and signaling activities. It participates in maintaining the balance of lipid composition among cell membranes. PITPNB does not function alone; it often acts as part of lipid transfer complexes collaborating with other proteins to execute its function properly.

Pathways

PITPNB plays an active role in phosphoinositide signaling and membrane trafficking pathways. These pathways are critical for cell signaling and membrane dynamics. PI4K2A and PI4KA are proteins related to these pathways and interact with PITPNB highlighting its contribution to complex intracellular signaling processes.

Defects in PITPNB have been linked to metabolic disorders and neurodegenerative diseases such as Alzheimer's. PITPNB is connected to APOE a protein involved in lipid metabolism and associated with Alzheimer's disease progression. Understanding the role of PITPNB in these conditions opens possibilities for therapeutic strategies targeting lipid transfer processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed : 10531358, PubMed : 18636990, PubMed : 20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed : 20332109).
See full target information PITPNB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 30:1417-1433.e7 PubMed32023459

2020

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Michael M Dubreuil,David W Morgens,Kanji Okumoto,Masanori Honsho,Kévin Contrepois,Brittany Lee-McMullen,Gavin McAllister Traber,Ria S Sood,Scott J Dixon,Michael P Snyder,Yukio Fujiki,Michael C Bassik
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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