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AB222078

Anti-PITPNC1 antibody

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Rabbit Polyclonal PITPNC1 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PITPNC1 aa 1-100.

View Alternative Names

Cytoplasmic phosphatidylinositol transfer protein 1, Mammalian rdgB homolog beta, Retinal degeneration B homolog beta, M-rdgB beta, MrdgBbeta, RdgBbeta, PITPNC1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-PITPNC1 antibody (AB222078)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PITPNC1 antibody (AB222078)

4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized PC-3 (human prostate adenocarcinoma cell line) cells stained for PITPNC1 (green) using ab222078 in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PITPNC1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9UKF7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Xenopus tropicalis": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PITPNC1 also known as Phosphatidylinositol Transfer Protein Cytoplasmic 1 is an important lipid transfer protein that binds to phosphatidylinositol and phosphatidylcholine. It plays a vital role in lipid signaling and membrane dynamics transporting phospholipids between cellular membranes. With a mass of approximately 36 kDa PITPNC1 is expressed in several tissues including the brain liver and lungs and highly in various cancerous tissues.
Biological function summary

PITPNC1 influences cellular growth movement and behavior. It is involved in the regulation of Golgi function and vesicular trafficking. PITPNC1 acts independently but can associate with other proteins influencing their functions. Studies suggest that PITPNC1 coordinates with vesicular transport complexes modifying intracellular signaling pathways.

Pathways

PITPNC1 integrates into key signaling cascades such as the phosphatidylinositol signaling pathway and the PI3K/AKT pathway. Its activity impacts PI3K signaling influencing cell proliferation and survival. PITPNC1 interacts with proteins like PIP2 and PIP3 which are important members of these pathways. Its role in these pathways offers insights into its broad functional impact in cells.

PITPNC1 has links to certain cancers and metabolic disorders. Its overexpression correlates with aggressive forms of cancer such as breast and colorectal cancer indicating its potential as a biomarker. In cancer PITPNC1 may facilitate metastasis by interacting with proteins like MMP9 (Matrix Metallopeptidase 9) and VEGFA (Vascular Endothelial Growth Factor A) influencing tumor progression and angiogenesis. Understanding PITPNC1's role offers opportunities for therapeutic targeting in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed : 10531358, PubMed : 22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16 : 0/16 : 1 and C16 : 1/18 : 1 PA species (PubMed : 22822086).. Isoform 2. Catalyzes the transfer of phosphatidylinositol between membranes.
See full target information PITPNC1
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Product promise

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