Rabbit Polyclonal PITPNC1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PITPNC1.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human PITPNC1. Database link Q9UKF7
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Isoform 1. Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). Isoform 2. Catalyzes the transfer of phosphatidylinositol between membranes.
Alternative names
Cytoplasmic phosphatidylinositol transfer protein 1, Mammalian rdgB homolog beta, Retinal degeneration B homolog beta, M-rdgB beta, MrdgBbeta, RdgBbeta, PITPNC1
Recommended products
Rabbit Polyclonal PITPNC1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PITPNC1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human PITPNC1. Database link Q9UKF7
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity >95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PITPNC1 also known as Phosphatidylinositol Transfer Protein Cytoplasmic 1 is an important lipid transfer protein that binds to phosphatidylinositol and phosphatidylcholine. It plays a vital role in lipid signaling and membrane dynamics transporting phospholipids between cellular membranes. With a mass of approximately 36 kDa PITPNC1 is expressed in several tissues including the brain liver and lungs and highly in various cancerous tissues.
- Biological function summary
PITPNC1 influences cellular growth movement and behavior. It is involved in the regulation of Golgi function and vesicular trafficking. PITPNC1 acts independently but can associate with other proteins influencing their functions. Studies suggest that PITPNC1 coordinates with vesicular transport complexes modifying intracellular signaling pathways.
- Pathways
PITPNC1 integrates into key signaling cascades such as the phosphatidylinositol signaling pathway and the PI3K/AKT pathway. Its activity impacts PI3K signaling influencing cell proliferation and survival. PITPNC1 interacts with proteins like PIP2 and PIP3 which are important members of these pathways. Its role in these pathways offers insights into its broad functional impact in cells.
- Associated diseases and disorders
PITPNC1 has links to certain cancers and metabolic disorders. Its overexpression correlates with aggressive forms of cancer such as breast and colorectal cancer indicating its potential as a biomarker. In cancer PITPNC1 may facilitate metastasis by interacting with proteins like MMP9 (Matrix Metallopeptidase 9) and VEGFA (Vascular Endothelial Growth Factor A) influencing tumor progression and angiogenesis. Understanding PITPNC1's role offers opportunities for therapeutic targeting in these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (ab238643)
Paraffin-embedded human thyroid tissue stained for PITPNC using ab238643 at 1/100 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (ab238643)
Paraffin-embedded human adrenal gland tissue stained for PITPNC using ab238643 at 1/100 dilution in immunohistochemical analysis.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com