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AB251739

Anti-PITPnm 3 antibody

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Rabbit Polyclonal PITPnm 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PITPNM3 aa 450 to C-terminus.

View Alternative Names

NIR1, PITPNM3, Membrane-associated phosphatidylinositol transfer protein 3, Pyk2 N-terminal domain-interacting receptor 1, PITPnm 3, NIR-1

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

Paraffin-embedded human kidney tissue stained for PITPnm 3 using ab251739 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

Paraffin-embedded human pancreas tissue stained for PITPnm 3 using ab251739 at 1/50 dilution in immunohistochemical analysis. Low expression as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

Paraffin-embedded human spleen tissue stained for PITPnm 3 using ab251739 at 1/50 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PITPnm 3 antibody (AB251739)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PITPnm 3 antibody (AB251739)

PFA-fixed, Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for PITPnm 3 (green) using ab251739 at 4 µg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

Paraffin-embedded human liver tissue stained for PITPnm 3 using ab251739 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPnm 3 antibody (AB251739)

Paraffin-embedded human cerebral cortex tissue stained for PITPnm 3 using ab251739 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PITPNM3 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BZ71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PITPnm 3 also known as phosphatidylinositol transfer protein cytoplasmic 1 has a mass of around 40 kDa. This protein functions by transferring phosphatidylinositol and phosphatidylcholine between membranes playing a role in lipid metabolism. It is expressed in various tissues including the brain liver and placenta. The presence of PITPnm 3 is important in maintaining proper membrane lipid composition and signaling pathways within these cells.
Biological function summary

The function of PITPnm 3 extends to regulating intracellular signaling by managing lipid interfaces. It supports the formation and dynamics of membrane structures which are necessary for vesicular trafficking and membrane curvature. The protein operates as part of the phosphoinositide signaling complex aiding in membrane identity and compartmentalization. Its role is essential for normal cellular communication and organelle function.

Pathways

The involvement of PITPnm 3 extends to the phosphoinositide cycle and the inositol lipid signaling pathway. This protein interacts with phospholipase C and Akt contributing to the production of secondary messengers which mediate various cellular responses including proliferation and survival. Such interactions link PITPnm 3 to signaling cascades that are important for maintaining cellular homeostasis and response to environmental stimuli.

The dysregulation of PITPnm 3 activity has been associated with neurodegenerative diseases like Alzheimer's disease and metabolic disorders such as diabetes. Misregulation can affect lipid signaling and membrane trafficking contributing to disease pathogenesis. The relationship between PITPnm 3 and proteins like tau in Alzheimer's or insulin signaling components in diabetes highlights its significant role in disease mechanisms. Understanding these connections aids in developing targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
See full target information PITPNM3
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Product promise

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For full details, please see our Terms & Conditions

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