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AB234670

Anti-PKD1L3 antibody

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(2 Publications)

Rabbit Polyclonal PKD1L3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PKD1L3 aa 1-200.

View Alternative Names

Polycystin-1-like protein 3, Polycystin-1L3, PC1-like 3 protein, Polycystic kidney disease protein 1-like 3, PKD1L3

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-PKD1L3 antibody (AB234670)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PKD1L3 antibody (AB234670)

A549 (Human lung carcinoma cell line) cells stained for PKD1L3 using ab234670 at a dilution of 1/100 in ICC/IF. Secondary antibody is an Alexa Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKD1L3 antibody (AB234670)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKD1L3 antibody (AB234670)

Paraffin-embedded human placenta tissue stained for PKD1L3 with ab234670 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKD1L3 antibody (AB234670)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKD1L3 antibody (AB234670)

Paraffin-embedded human heart tissue stained for PKD1L3 with ab234670 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PKD1L3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q7Z443

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PKD1L3 also known as Polycystic Kidney Disease 1-Like 3 is a protein involved in mechanosensation and ion channel activity. It has an estimated molecular mass of approximately 250 kDa. PKD1L3 is part of the TRPP channel family and is known for forming channels with the related protein PKD2L1. Expression of PKD1L3 occurs in various tissues including the tongue where it participates in taste perception processes.
Biological function summary

The protein functions as a subunit of a nonselective ion channel complex that contributes to sensory functions. PKD1L3 together with PKD2L1 forms ion channels that respond to environmental changes including pH alterations. This tetrameric channel complex plays a role in taste perception and is known to mediate sour taste reception in taste cells.

Pathways

Researchers have found that PKD1L3 participates in the sensory transduction pathway specifically in taste reception. It works closely with PKD2L1 to form functional complexes essential for sour taste perception. The involvement of PKD1L3 in these pathways along with its interaction with PKD2L1 highlights its role in signal transduction processes related to sensory perception.

PKD1L3 relates to polycystic kidney disease and taste disorders. Mutations or alterations in PKD1L3 along with PKD2L1 may contribute to these conditions impacting normal function and potentially leading to sensory deficits or pathological kidney functions. The connection between PKD1L3 and PKD2L1 highlights their combined influence in these conditions providing insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed : 19464260, PubMed : 23212381). Also shows permeability towards NA(1+), K(+) and Mg(2+) (PubMed : 23212381). Heterotetrameric complex channel is activated by external low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed : 19464260, PubMed : 23212381). May act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed : 19812697).
See full target information PKD1L3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Virus research 355:199570 PubMed40188851

2025

Common host factors for internal ribosomal entry site-mediated translation of viral genomic RNA: An investigation in foot-and-mouth disease and classical swine fever viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Rupaly Akhter,Kazi Anowar Hossain,Bouchra Kitab,Yoshihiro Sakoda,Kyoko Tsukiyama-Kohara

International journal of molecular sciences 24: PubMed37298606

2023

Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole.

Applications

Unspecified application

Species

Unspecified reactive species

Wai Kit Chia,Pik Yuen Chia,Nor Haslinda Abdul Aziz,Salwati Shuib,Muaatamarulain Mustangin,Yoke Kqueen Cheah,Teck Yee Khong,Yin Ping Wong,Geok Chin Tan
View all publications
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Product promise

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