Anti-Placental alkaline phosphatase (PLAP) antibody
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(1 Publication)
Rabbit Polyclonal PPB1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ALPP aa 150-250.
View Alternative Names
PLAP, ALPP, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-Placental alkaline phosphatase (PLAP) antibody (AB243731)
PFA fixed, Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling Placental alkaline phosphatase (PLAP) using ab243731 at 4 μg/ml (green) in ICC/IF.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental alkaline phosphatase (PLAP) antibody (AB243731)
Formalin-fixed, paraffin-embedded human placenta tissue stained for Placental alkaline phosphatase (PLAP) with ab243731 at a 1/50 dilution in immunohistochemical analysis.
- WB
Supplier Data
Western blot - Anti-Placental alkaline phosphatase (PLAP) antibody (AB243731)
All lanes:
Western blot - Anti-Placental alkaline phosphatase (PLAP) antibody (ab243731) at 0.4 µg/mL
All lanes:
Human placenta tissue lysate
Predicted band size: 58 kDa
false
Reactivity data
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Supplementary information
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Biological function summary
PLAP shows importance in bone mineralization and fetal development. It participates in the hydrolysis of phosphate esters influencing nutrient availability and metabolism. PLAP is not a part of major protein complexes; however its enzymatic activity directly affects local phosphate concentrations which are critical for processes like bone formation and tissue regeneration during pregnancy.
Pathways
PLAP expression and activity intersect significantly with phosphate metabolism and fetal development pathways. The alkaline phosphatase family plays central roles in these pathways and PLAP shares functions with other isoenzymes in the family such as the tissue nonspecific alkaline phosphatase. These enzymes regulate phosphate turnover and contribute to essential developmental processes.
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Target data
Publications (1)
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Placenta 160:118-125 PubMed39793469
2025
Applications
Unspecified application
Species
Unspecified reactive species
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