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AB15555

Anti-Placental lactogen antibody, prediluted

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(1 Publication)

Rabbit Polyclonal CSH2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Chorionic somatomammotropin hormone 2, Choriomammotropin, Lactogen, Placental lactogen, PL, CSH2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody, prediluted (AB15555)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody, prediluted (AB15555)

ab15554 staining Human placenta by Immunohistochemistry (FFPE-sections).

This data was developed using the undiluted version of this antibody (ab15554).

Western blot - Anti-Placental lactogen antibody, prediluted (AB15555)
  • WB

Unknown

Western blot - Anti-Placental lactogen antibody, prediluted (AB15555)

This data was developed using the undiluted version of this antibody (ab15554).

Lane 1:

Western blot - Anti-Placental lactogen antibody (<a href='/en-us/products/primary-antibodies/placental-lactogen-antibody-ab15554'>ab15554</a>) at 1/25 dilution

Lane 1:

Western blot - Anti-Placental lactogen antibody, prediluted (ab15555) at 1/25 dilution

All lanes:

Human placenta lysate

Predicted band size: 25 kDa

Observed band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/25", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1", "IHCP-species-notes": "<p>10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes. ab15555 shows cytoplasmic staining.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: Tris buffered saline, 1% BSA
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Placental lactogen also known as chorionic somatomammotropin hormone is a glycoprotein hormone with a molecular mass of approximately 22 kDa. The hormone is primarily expressed in the syncytiotrophoblasts of the placenta during pregnancy. It shares structural similarities with other hormones like growth hormone and prolactin due to its polypeptide nature. Placental lactogen influences various physiological processes related to maternal and fetal development.
Biological function summary

Placental lactogen functions to modulate maternal metabolism to support fetal growth and development. It promotes changes in the maternal glucose metabolism ensuring an adequate energy supply to the fetus. This protein also stimulates mammary gland development preparing the mother for lactation. It does not form part of a larger protein complex acting independently in the biological processes it regulates.

Pathways

Researchers have found that placental lactogen plays a role in both the insulin-like growth factor (IGF) pathway and the JAK-STAT signaling pathway. It interacts with the IGF pathway to enhance nutrient uptake and fetal growth. Additionally its role in the JAK-STAT pathway ties it to immune modulation and cell proliferation. Placental lactogen is related to proteins such as the growth hormone and prolactin within these pathways due to their shared structural properties and similar mechanisms of action.

Studies have linked abnormal levels of placental lactogen to gestational diabetes mellitus and pre-eclampsia. Gestational diabetes arises when placental lactogen induces higher insulin resistance impacting maternal glucose regulation. Pre-eclampsia may involve imbalance in placental lactogen expression affecting placental vascular function. Researchers have noted interactions with proteins like leptin and insulin as these relate to glucose metabolism and vascular changes in pregnancy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
See full target information CSH2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37834175

2023

Derivation of Arbas Cashmere Goat Induced Pluripotent Stem Cells in LCDM with Trophectoderm Lineage Differentiation and Interspecies Chimeric Abilities.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Liu,Jing Wang,Yongli Yue,Chen Li,Xuemin Zhang,Jinzhu Xiang,Hanning Wang,Xueling Li
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Product promise

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