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AB18096

Anti-Plasma Cell antibody [SPM310], prediluted

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(1 Publication)

Mouse Monoclonal Plasma Cell antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing Plasma Cell protein.
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Cell antibody [SPM310], prediluted (AB18096)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Cell antibody [SPM310], prediluted (AB18096)

Human tonsil stained with ab18096.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SPM310

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

We have data to indicate that this antibody may not cross react with Rat. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1", "IHCP-species-notes": "<p></p> Perform enzymatic antigen retrieval before commencing with IHC staining protocol." } } }
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Product details

The concentration of this prediluted antibody is 4µg/ml.
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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plasma cells also referred to as antibody-producing cells are a type of differentiated B lymphocytes. These cells produce large amounts of antibodies and have a critical role in the immune response. Plasma cells are typically found in the bone marrow after they migrate from the lymphoid tissues where they undergo differentiation. Each plasma cell has unique antibodies that are specific to different antigens. Plasma cells are relatively large roughly 14-20 micrometers in diameter and they exhibit a high cytoplasmic volume due to rough endoplasmic reticulum abundance needed for antibody synthesis.
Biological function summary

Plasma cells synthesize and secrete antibodies which are important for identifying and neutralizing pathogens such as bacteria and viruses. These cells play an essential role in humoral immunity one of the main pathways of the adaptive immune system. Plasma cells are often part of multimolecular complexes due to their association with various immune components to create a coordinated immune response. The antibodies secreted by plasma cells bind to antigens marking them for destruction by other immune cells.

Pathways

Plasma cells are integral to the adaptive immune response and play a central role in the IgG and IgA isotype switching pathways. These pathways lead the change of antibody classes to target pathogens more effectively. Plasma cells interact closely with T-helper cells which release cytokines that influence plasma cell function and antibody production. This interaction ensures effective communication and response to specific antigens within the immune system.

Plasma cells are associated with multiple myeloma and Waldenström’s macroglobulinemia which are types of blood cancer. In multiple myeloma plasma cells grow uncontrollably leading to the overproduction of a single type of weak antibody. This causes various complications and weakens the immune system. Plasma cells in these conditions also have connections to related proteins like beta-2 microglobulin which serve as a marker to monitor disease progression. Understanding plasma cells and their roles can help in developing therapeutic approaches for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Plasma Cell
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Reproductive sciences (Thousand Oaks, Calif.) 21:63-71 PubMed23653390

2013

Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel M Kraus,Liping Feng,R Phillips Heine,Haywood L Brown,Kathleen M Caron,Amy P Murtha,Chad A Grotegut
View all publications
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Product promise

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