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AB44392

Anti-Plasma Kallikrein 1B antibody

5

(6 Reviews)

|

(4 Publications)

Rabbit Polyclonal Plasma Kallikrein 1B antibody. Suitable for ELISA, WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human KLKB1.

View Alternative Names

KLK3, KLKB1, Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, PKK

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ELISA, IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human KLKB1. The exact immunogen used to generate this antibody is proprietary information.

P03952

Specificity

This antibody is specific for Plasma Kallikrein 1B (amino end of the catalytic domain).

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plasma Kallikrein 1B also known as PKK or KLKB1 is a serine protease enzyme with an approximate mass of 88 kDa. It is important for the blood coagulation process. This protein is mainly expressed in the liver and circulates in the blood as the inactive precursor prekallikrein. Through cleavage prekallikrein converts into its active form plasma kallikrein. Plasma kallikrein exhibits various proteolytic activities influencing multiple substrates involved in hemostatic and inflammatory responses.
Biological function summary

Plasma Kallikrein 1B plays significant roles in the kinin-kallikrein system. Within this system it cleaves high-molecular-weight kininogen to release bradykinin a potent vasodilator. This enzyme is not part of a larger protein complex but operates independently to modulate various physiological responses. Plasma kallikrein's activity influences processes like pain vasodilation and inflammation making it important in homeostasis and acute-phase responses.

Pathways

Plasma Kallikrein 1B participates actively in the kallikrein-kinin and the contact activation pathways. In the kallikrein-kinin system it works alongside high-molecular-weight kininogen and factor XII which plays an important role in the intrinsic pathway of coagulation. Plasma kallikrein's enzymatic activities lead to the production of bradykinin and other peptides impacting blood pressure and inflammatory processes.

Plasma Kallikrein 1B associates strongly with hereditary angioedema and diabetic retinopathy. In hereditary angioedema its dysregulation leads to excessive bradykinin production causing episodes of swelling. In diabetic retinopathy elevated plasma kallikrein activity can exacerbate vascular complications. Plasma kallikrein's disorderly activities also connect it to other proteins like C1 inhibitor in these pathological conditions highlighting its importance in clinical studies.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
See full target information KLKB1

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Zoological research 45:1001-1012 PubMed39147715

2024

Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Na Cha,Juan Yang,Jin-Ai Gao,Xin Lu,Xiao-Long Chang,Rebecca Caroline Thuku,Qi Liu,Qiu-Min Lu,Dong-Sheng Li,Ren Lai,Ming-Qian Fang

Frontiers in pharmacology 14:1287487 PubMed38178859

2024

Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation.

Applications

Unspecified application

Species

Unspecified reactive species

Allen C Clermont,Nivetha Murugesan,Hannah J Edwards,Daniel K Lee,Natasha P Bayliss,Edward J Duckworth,Stephen J Pethen,Sally L Hampton,David Gailani,Edward P Feener

Science advances 7: PubMed33523981

2021

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Rasmus Pihl,Rasmus K Jensen,Emil C Poulsen,Lisbeth Jensen,Annette G Hansen,Ida B Thøgersen,József Dobó,Péter Gál,Gregers R Andersen,Jan J Enghild,Steffen Thiel

Brain : a journal of neurology 143:1780-1797 PubMed32428221

2020

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenwei Yu,Min Shi,Tessandra Stewart,Pierre-Olivier Fernagut,Yang Huang,Chen Tian,Benjamin Dehay,Anzari Atik,Dishun Yang,Francesca De Giorgi,François Ichas,Marie-Hélène Canron,Roberto Ceravolo,Daniela Frosini,Han-Joon Kim,Tao Feng,Wassilios G Meissner,Jing Zhang
View all publications

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