AB207494

Anti-Plasmodium aldolase antibody

Name: Anti-Plasmodium aldolase antibody (ab207494) | Abcam
Brand: Abcam Limited
SKU: AB207494
Price: 525 USD
Availability: InStock

(1 Review)

(28 Publications)

Rabbit Polyclonal ALF antibody. Suitable for ELISA, WB and reacts with Plasmodium falciparum samples. Cited in 28 publications.

View Alternative Names

PF14_0425, PF3D7_1444800, FBPA, Fructose-bisphosphate aldolase

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Plasmodium falciparum

Applications

WB, ELISA

applications

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plasmodium aldolase also known as ALD or aldolase MW is an important enzyme in the glycolytic pathway. It has a molecular weight of approximately 39 kDa. The enzyme catalyzes the reversible cleavage of fructose-16-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is important for energy production in the parasite Plasmodium which causes malaria. Plasmodium aldolase is expressed in various stages of the parasite's life cycle including the erythrocytic stage where the parasite infects red blood cells.

Biological function summary

Plasmodium aldolase plays a significant role in the survival and replication of the malaria parasite. It is not part of a larger protein complex but often associates with the cytoskeleton within the parasite facilitating its structural integrity and mobility. The enzyme's activity directly impacts the energy metabolism of Plasmodium making it essential for parasite survival and development in the host.

Pathways

Enzymes like Plasmodium aldolase operate within glycolytic and gluconeogenic pathways which are central to carbohydrate metabolism. In the glycolytic pathway aldolase sequentially interacts with proteins such as glyceraldehyde-3-phosphate dehydrogenase. Through its function in energy production aldolase indirectly supports various biosynthetic reactions and parasitic replication processes specific to Plasmodium.

Disturbances in Plasmodium aldolase function are directly linked to malaria one of the major global infectious diseases. The enzyme itself is a target for antimalarial drug development as inhibitors could potentially disrupt parasite energy metabolism leading to its death. Research also indicates a connection between aldolase and another protein lactate dehydrogenase which facilitates the parasite's anaerobic metabolism thereby contributing to its adaptability under different oxygen conditions in the human host.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed : 26289816). Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (Probable) (PubMed : 22991428, PubMed : 25261592). Stimulates actin polymerisation (PubMed : 25261592).

See full target information FBPA

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Publications (28)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1013275 PubMed40694565

2025

A chaperonin complex regulates organelle proteostasis in malaria parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda Tissawak,Yarden Rosin,Shirly Katz Galay,Alia Qasem,Michal Shahar,Nirit Trabelsi,Ora Furman-Schueler,Steven M Johnson,Anat Florentin

Antimicrobial agents and chemotherapy 68:e0165923 PubMed39028193

2024

Indigenous emergence and spread of C469Y artemisinin-resistant in Uganda.

Applications

Unspecified application

Species

Unspecified reactive species

Phyllis Awor,Romain Coppée,Nimol Khim,Laurine Rondepierre,Camille Roesch,Chanra Khean,Chanvong Kul,Rotha Eam,Thornleaksmey Lorn,Proscovia Athieno,Joseph Kimera,Betty Balikagala,Emmanuel I Odongo-Aginya,Denis A Anywar,Toshihiro Mita,Jérôme Clain,Pascal Ringwald,Aita Signorell,Christian Lengeler,Christian Burri,Frédéric Ariey,Manuel W Hetzel,Benoit Witkowski

Nature communications 15:5794 PubMed38987258

2024

Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus.

Applications

Unspecified application

Species

Unspecified reactive species

Jiahong Li,Gerald J Shami,Benjamin Liffner,Ellie Cho,Filip Braet,Manoj T Duraisingh,Sabrina Absalon,Matthew W A Dixon,Leann Tilley

mSphere 9:e0014024 PubMed38564734

2024

MYST regulates DNA repair and forms a NuA4-like complex in the malaria parasite .

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad Kalamuddin,Ahmad Rushdi Shakri,Chengqi Wang,Hui Min,Xiaolian Li,Liwang Cui,Jun Miao

mBio 15:e0351023 PubMed38470053

2024

selectively degrades α-spectrin of infected erythrocytes after invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Kexin Zheng,Qilong Li,Ning Jiang,Yanxin Zhang,Yuxin Zheng,Yiwei Zhang,Ying Feng,Ran Chen,Xiaoyu Sang,Qijun Chen

PLoS pathogens 19:e1011899 PubMed38150475

2023

Malaria parasite centrins can assemble by Ca2+-inducible condensation.

Applications

Unspecified application

Species

Unspecified reactive species

Yannik Voß,Severina Klaus,Nicolas P Lichti,Markus Ganter,Julien Guizetti

eLife 12: PubMed38108809

2023

Atlas of intraerythrocytic development using expansion microscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin Liffner,Ana Karla Cepeda Diaz,James Blauwkamp,David Anaguano,Sonja Frolich,Vasant Muralidharan,Danny W Wilson,Jeffrey D Dvorin,Sabrina Absalon

Nature communications 14:5086 PubMed37607941

2023

Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

Gayani Batugedara,Xueqing M Lu,Borislav Hristov,Steven Abel,Zeinab Chahine,Thomas Hollin,Desiree Williams,Tina Wang,Anthony Cort,Todd Lenz,Trevor A Thompson,Jacques Prudhomme,Abhai K Tripathi,Guoyue Xu,Juliana Cudini,Sunil Dogga,Mara Lawniczak,William Stafford Noble,Photini Sinnis,Karine G Le Roch

PLoS pathogens 19:e1011468 PubMed37384799

2023

The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Stephan Wichers-Misterek,Ralf Krumkamp,Jana Held,Heidrun von Thien,Irene Wittmann,Yannick Daniel Höppner,Julia M Ruge,Kara Moser,Antoine Dara,Jan Strauss,Meral Esen,Rolf Fendel,Zita Sulyok,Myriam D Jeninga,Peter G Kremsner,B Kim Lee Sim,Stephen L Hoffman,Michael F Duffy,Thomas D Otto,Tim-Wolf Gilberger,Joana C Silva,Benjamin Mordmüller,Michaela Petter,Anna Bachmann

Journal of cell science 136: PubMed36744402

2023

An essential endoplasmic reticulum-resident N-acetyltransferase ortholog in Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Polino,Muhammad M Hasan,Katherine Floyd,Yolotzin Avila-Cruz,Yujuan Yang,Daniel E Goldberg

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Plasmodium aldolase antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (28)

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