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AB210099

Anti-Plastin L antibody

4

(3 Reviews)

|

(4 Publications)

Rabbit Polyclonal Plastin L antibody. Suitable for IHC - Wmt, IHC-P and reacts with Zebrafish samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish lcp1 aa 50-450.

View Alternative Names

pls2, lcp1, Plastin-2, L-plastin, Lymphocyte cytosolic plastin 1

2 Images
IHC - Wholemount - Anti-Plastin L antibody (AB210099)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-Plastin L antibody (AB210099)

ab210099 detects Lcp1 protein on whole mount zebrafish by immunohistochemical analysis.
Sample : Paraformaldehyde-fixed 2 days-post-fertilization zebrafish embryo.
Green : Lcp1 stained by Lcp1 antibody diluted at a 1/100 dilution.
Antigen Retrieval : Tris-HCl buffer, pH 9.0, 20 min at 70°C

IHC - Wholemount - Anti-Plastin L antibody (AB210099)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-Plastin L antibody (AB210099)

ab210099 detects Lcp1 protein on whole mount 2 day-post-fertilization zebrafish embryo by immunohistochemical analysis at a 1/100 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Zebrafish

Applications

IHC - Wmt, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Zebrafish lcp1 aa 50-450. The exact immunogen used to generate this antibody is proprietary information.

Q6P698

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/100 - 1/500", "IHCWmt-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using 1mM EDTA-NaOH (pH8.0) 95°C, 1 Hour</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plastin L also known as L-Plastin or plastine is a type of actin-bundling protein involved in regulating cytoskeletal rearrangements. This protein has a mass of approximately 70 kDa and serves an essential role in maintaining cell structure and mobility by cross-linking actin filaments. It is predominantly found in hematopoietic cells such as leukocytes but also expressed in certain non-hematopoietic cells. In zebrafish studies plastin L has been important for understanding its conservation and function across species.
Biological function summary

Plastin L participates in cellular processes such as phagocytosis cell motility and immune responses by stabilizing actin filaments. It does not form part of a larger protein complex but interacts with actin to perform its functions. As an actin-binding protein it helps in the formation and maintenance of the cytoskeleton impacting the cell's mechanical properties and response to external stimuli.

Pathways

Plastin L plays significant roles in immune cell signaling and cytoskeletal rearrangements. It is involved in pathways such as the immune response and cell adhesion where it contributes to leukocyte emigration and inflammation. Plastin L is functionally related to proteins like talin and paxillin which are key in mediating signal transduction resulting in cytoskeletal remodeling.

Plastin L is associated with cancer and immune system disorders. Overexpression of plastin L correlates with various forms of cancer highlighting its role in tumor cell invasion and metastasis. Additionally it shows a connection with autoimmune conditions where deregulation of actin polymerization affects immune cell function. In these contexts proteins like cofilin interact with plastin L to modulate actin dynamics and cellular responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Actin-binding protein. Plays a role in the activation of T-cells (By similarity).
See full target information lcp1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 13:e70259 PubMed39991785

2025

Microinjection of angiotensin II into zebrafish embryos induces transient dilation and elastin disruption of the dorsal aorta.

Applications

Unspecified application

Species

Unspecified reactive species

Shota Tanifuji,Keiko Uchida,Genri Kawahara,Takashi Nakamura,Saki Iida,Yukiko K Hayashi,Utako Yokoyama

Cell death discovery 9:441 PubMed38057295

2023

A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes.

Applications

Unspecified application

Species

Unspecified reactive species

Rudy Celeghin,Giovanni Risato,Giorgia Beffagna,Marco Cason,Maria Bueno Marinas,Mila Della Barbera,Nicola Facchinello,Alice Giuliodori,Raquel Brañas Casas,Micol Caichiolo,Andrea Vettori,Enrico Grisan,Stefania Rizzo,Luisa Dalla Valle,Francesco Argenton,Gaetano Thiene,Natascia Tiso,Kalliopi Pilichou,Cristina Basso

Cell host & microbe 29:58-67.e5 PubMed33120115

2020

Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin K Takaki,Gabriel Rinaldi,Matthew Berriman,Antonio J Pagán,Lalita Ramakrishnan

Molecular medicine reports 21:731-743 PubMed31974592

2020

Comparative proteomic and genomic analyses of Brucella abortus biofilm and planktonic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Taishan Tang,Guoqiang Chen,Aizhen Guo,Ye Xu,Linli Zhao,Mengrui Wang,Chengping Lu,Yuan Jiang,Changyin Zhang
View all publications
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