AB181816

Anti-PLCZ1 antibody

Name: Anti-PLCZ1 antibody (ab181816) | Abcam
Brand: Abcam Limited
SKU: AB181816

Be the first to review this product! Submit a review

(3 Publications)

Rabbit Polyclonal PLCZ1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PLCZ1.

View Alternative Names

Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, Testis-development protein NYD-SP27, PLC-zeta-1, PLCZ1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLCZ1 antibody (AB181816)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLCZ1 antibody (AB181816)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus endometrium tissue labeling PLCZ1 with ab181816 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PLCZ1. The exact immunogen used to generate this antibody is proprietary information.

Q86YW0

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

See full target information PLCZ1

style

left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Reproduction (Cambridge, England) 168: PubMed39042720

2024

Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Li,Juncen Guo,Gelin Huang,Nan Wu,Su Chen,Jing Dai,Xueguang Zhang,Guohui Zhang,Weiwei Zhi,Jierui Yan,Rui Zheng,Fei Yan,Zheng Yan,Ling Wu,Sixian Wu,Zhiliang Ji,Jiuzhi Zeng,Ge Lin,Bin Li,Wenming Xu

Nutrients 15: PubMed37299553

2023

Pecans and Its Polyphenols Prevent Obesity, Hepatic Steatosis and Diabetes by Reducing Dysbiosis, Inflammation, and Increasing Energy Expenditure in Mice Fed a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Delgadillo-Puga,Ivan Torre-Villalvazo,Lilia G Noriega,Leonardo A Rodríguez-López,Gabriela Alemán,Erik A Torre-Anaya,Yonatan Y Cariño-Cervantes,Berenice Palacios-Gonzalez,Janette Furuzawa-Carballeda,Armando R Tovar,Luis Cisneros-Zevallos

Laboratory investigation; a journal of technical methods and pathology 100:583-595 PubMed31857692

2019

Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Woojin Kang,Yuichirou Harada,Kenji Yamatoya,Natsuko Kawano,Seiya Kanai,Yoshitaka Miyamoto,Akihiro Nakamura,Mami Miyado,Yoshiki Hayashi,Yoko Kuroki,Hidekazu Saito,Yasuhiro Iwao,Akihiro Umezawa,Kenji Miyado

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PLCZ1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLCZ1 antibody (AB181816)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (3)

Product promise