Anti-Pleckstrin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Pleckstrin also known as PLEK is a phosphoprotein with a mass of approximately 40 kDa. It is predominantly expressed in platelets and leukocytes. Pleckstrin is the major protein kinase C substrate in platelets and acts as an important mediator in signal transduction processes. Its structure includes pleckstrin homology domains which play key roles in interacting with other cellular proteins and in lipid binding.

Biological function summary

Pleckstrin participates in cellular processes like cytoskeletal rearrangement and cell motility. It functions as part of protein signaling complexes that regulate actin cytoskeleton dynamics. Through its pleckstrin homology domains pleckstrin binds to phosphatidylinositol lipids which is critical for recruitment to membrane sites required for cellular activation and response.

Pathways

Pleckstrin is intricately involved in the PI3K/AKT signaling pathway and the platelet activation pathway. Within these pathways pleckstrin interacts with proteins like G-protein coupled receptors and PI3K facilitating cellular responses to external stimuli. These processes ensure platelets function correctly during hemostasis and inflammatory responses.

Associated diseases and disorders

Pleckstrin's role is critical in diseases like thrombocytopenia and psoriasis. Aberrations in pleckstrin expression or function can lead to improper platelet function contributing to abnormal bleeding or clotting scenarios in thrombocytopenia. It is also connected with proteins like PIP3 and AKT which are involved in pathways that can become dysregulated in chronic inflammatory disorders such as psoriasis.