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AB233826

Anti-Plexin A1 antibody [7B8H9]

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(1 Publication)

Mouse Monoclonal Plexin A1 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLXNA1 aa 1100-1200.

View Alternative Names

NOV, PLXN1, PLXNA1, Plexin-A1, Semaphorin receptor NOV

3 Images
Flow Cytometry - Anti-Plexin A1 antibody [7B8H9] (AB233826)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Plexin A1 antibody [7B8H9] (AB233826)

Flow cytometric analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cell line labeling Plexin A1 with ab233826 at 1/200 dilution (green) compared with a negative control (red).

Western blot - Anti-Plexin A1 antibody [7B8H9] (AB233826)
  • WB

Supplier Data

Western blot - Anti-Plexin A1 antibody [7B8H9] (AB233826)

All lanes:

Western blot - Anti-Plexin A1 antibody [7B8H9] (ab233826) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 2:

Plexin A1 (aa 1100-1200)-hIgGFc transfected HEK-293 cell lysate

Predicted band size: 211 kDa

true

Western blot - Anti-Plexin A1 antibody [7B8H9] (AB233826)
  • WB

Supplier Data

Western blot - Anti-Plexin A1 antibody [7B8H9] (AB233826)

All lanes:

Western blot - Anti-Plexin A1 antibody [7B8H9] (ab233826) at 1/500 dilution

All lanes:

Recombinant human Plexin A1 (AA: 1100-1200) protein

Predicted band size: 211 kDa

true

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

7B8H9

Isotype

IgG2b

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Fragment Protein within Human PLXNA1 aa 1100-1200. The exact immunogen used to generate this antibody is proprietary information.

Q9UIW2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plexin A1 also known as PLXNA1 is a transmembrane protein that acts as a receptor for semaphorin proteins. It is involved in signaling pathways that guide cell migration and axonal growth. This protein has a molecular mass of around 220 kDa. Plexin A1 is expressed in several tissues including the nervous system where it plays a significant role in neural development. The expression levels can vary depending on the tissue type indicating its diverse functions across different biological contexts.
Biological function summary

Plexin A1 functions in neural patterning and the immune response. It is a part of semaphorin signaling complexes that include neuropilins and other plexins. These complexes are critical in translating extracellular cues into intracellular responses impacting cellular dynamics such as motility and adhesion. Plexin A1 also interacts with various intracellular signaling molecules influencing actin cytoskeleton reorganization which is essential for proper neural development.

Pathways

Plexin A1 participates in semaphorin signaling and cytoskeletal dynamics pathways. It interacts with Sema3A and Sema4D proteins which are key signaling semaphorins. These interactions regulate cellular movement by influencing the activity of downstream effectors like Rho and Rac GTPases. The involvement of Plexin A1 in these pathways is important for processes like axon guidance and neuronal connectivity.

Plexin A1 has association with cancer progression and neurodevelopmental disorders. Altered expression levels of Plexin A1 can lead to dysfunction in semaphorin-mediated signaling contributing to conditions such as autism spectrum disorders and tumor metastasis. The protein interacts with Met a receptor tyrosine kinase known to be involved in cancer linking Plexin A1 with oncogenic pathways and providing insights into its role in pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.
See full target information PLXNA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Archives of medical science : AMS 20:1631-1654 PubMed39649262

2023

Oxymatrine inhibits the development of radioresistance in NSCLC cells by reversing EMT through the DcR3/AKT/GSK-3β pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jianming Tang,Yu Cao,Hong Zhang,Rui Wang
View all publications
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